The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332.
Division of Cardiology, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322.
J Biomech Eng. 2021 Oct 1;143(10). doi: 10.1115/1.4051119.
The field of tissue engineering has been continuously evolving since its inception over three decades ago with numerous new advancements in biomaterials and cell sources and widening applications to most tissues in the body. Despite the substantial promise and great opportunities for the advancement of current medical therapies and procedures, the field has yet to capture wide clinical translation due to some remaining challenges, including oxygen availability within constructs, both in vitro and in vivo. While this insufficiency of nutrients, specifically oxygen, is a limitation within the current frameworks of this field, the literature shows promise in new technological advances to efficiently provide adequate delivery of nutrients to cells. This review attempts to capture the most recent advances in the field of oxygen transport in hydrogel-based tissue engineering, including a comparison of current research as it pertains to the modeling, sensing, and optimization of oxygen within hydrogel constructs as well as new technological innovations to overcome traditional diffusion-based limitations. The application of these findings can further the advancement and development of better hydrogel-based tissue engineered constructs for future clinical translation and adoption.
组织工程领域自三十多年前成立以来一直在不断发展，生物材料和细胞来源方面有了许多新的进展，应用范围也扩大到了人体的大多数组织。尽管目前的医学治疗和程序有很大的发展潜力和机会，但该领域尚未广泛应用于临床，这是因为它还存在一些挑战，包括构建体中（无论是体外还是体内）的氧气供应。虽然这种营养物质（特别是氧气）的不足是该领域当前框架的一个限制，但文献表明，新技术的进步有望有效地为细胞提供足够的营养物质输送。本文综述了水凝胶组织工程中氧传输领域的最新进展，包括对水凝胶构建体中氧的建模、传感和优化方面的当前研究的比较，以及克服传统扩散限制的新技术创新。这些发现的应用可以进一步推动更好的基于水凝胶的组织工程构建体的发展和开发，以促进未来的临床转化和应用。
