Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno University of Technology, Brno 601 90, Czech Republic.
J Biomech Eng. 2021 Oct 1;143(10). doi: 10.1115/1.4051120.
The paper aims at evaluation of mechanical tests of soft tissues and creation of their representative stress-strain responses and respective constitutive models. Interpretation of sets of experimental results depends highly on the approach to the data analysis. Their common representation through mean and standard deviation may be misleading and give nonrealistic results. In the paper, raw data of seven studies consisting of 11 experimental data sets (concerning carotid wall and atheroma tissues) are re-analyzed to show the importance of their rigorous analysis. The sets of individual uniaxial stress-stretch curves are evaluated using three different protocols: stress-based, stretch-based, and constant-based, and the population-representative response is created by their mean or median values. Except for nearly linear responses, there are substantial differences between the resulting curves, being mostly the highest for constant-based evaluation. But also the stretch-based evaluation may change the character of the response significantly. Finally, medians of the stress-based responses are recommended as the most rigorous approach for arterial and other soft tissues with significant strain stiffening.
本文旨在评估软组织的力学测试，并创建其具有代表性的应力-应变响应和相应的本构模型。对实验结果的解释在很大程度上取决于数据分析的方法。通过平均值和标准差对其进行共同表示可能会产生误导，并得出不切实际的结果。在本文中，重新分析了由七个研究组成的原始数据，共 11 个实验数据集（涉及颈动脉壁和动脉粥样硬化组织），以显示其严格分析的重要性。使用三种不同的方案评估了个体单轴应力-应变曲线集：基于应力的、基于应变的和基于常数的，并通过平均值或中位数创建了具有代表性的群体响应。除了几乎呈线性的响应外，所得曲线之间存在显著差异，基于常数的评估结果通常最高。但基于应变的评估也可能显著改变响应的特征。最后，建议将基于应力的响应中位数作为具有显著应变硬化的动脉和其他软组织的最严格方法。
