Department of Urology, Federal Armed Services Hospital Koblenz, Koblenz, Germany.
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Curr Opin Urol. 2021 Jul 1;31(4):304-314. doi: 10.1097/MOU.0000000000000894.
Several instruments have been designed to evaluate health-related quality of life (HRQoL) in patients with bladder cancer (BC). However, they vary in purpose, domains, and quality. To identify QoL instruments that have been validated for BC patients and to critically assess their domains and limitations.
Of the 11 instruments identified, seven have been externally validated. Of these, four can be used across all disease states; two are available for QoL assessment in patients with non-muscle invasive bladder cancer (NMIBC); and the European Organisation for Research and Treatment of Cancer (EORTC) module is intended for use together with a generic cancer-specific tool. Of the three instruments available to assess QoL in patients with muscle invasive bladder cancer (MIBC), EORTC Quality of Life Questionnaire-Bladder Cancer Muscle Invasive30 (QLQ-BLM30) and Functional Assessment of Cancer Therapy-Bladder-Cystectomy (FACT-Bl-Cys) need to be used each with their respective generic core questionnaire, whereas Ileal Orthotopic Neobladder-Pro Questionnaire is intended only to evaluate patients who have received an orthotopic neobladder.The core domains assessed by these instruments include social functioning, mental health, physical function, urinary function and sexual function.
No optimal BC-specific QoL instruments exist. Multiple cancer- and BC-specific instruments are required to cover each of the relevant domains. Selected tools should be reviewed within the context of specific research objectives.
已经设计了几种工具来评估膀胱癌（BC）患者的健康相关生活质量（HRQoL）。然而，它们在目的、领域和质量上存在差异。确定已针对 BC 患者进行验证的 QoL 工具，并批判性地评估其领域和局限性。
在确定的 11 种工具中，有 7 种经过了外部验证。其中，有 4 种可用于所有疾病状态；有 2 种可用于非肌肉浸润性膀胱癌（NMIBC）患者的 QoL 评估；欧洲癌症研究与治疗组织（EORTC）模块旨在与通用癌症特异性工具一起使用。在 3 种可用于评估肌层浸润性膀胱癌（MIBC）患者 QoL 的工具中，EORTC 膀胱癌 30 项生活质量问卷（QLQ-BLM30）和癌症治疗功能评估-膀胱-膀胱切除术（FACT-Bl-Cys）需要分别与各自的通用核心问卷一起使用，而回肠原位新膀胱问卷仅用于评估接受原位新膀胱的患者。这些工具评估的核心领域包括社交功能、心理健康、身体功能、尿功能和性功能。
目前没有针对 BC 的最佳 QoL 工具。需要多种癌症和 BC 特异性工具来涵盖每个相关领域。应根据特定的研究目标来审查选定的工具。
