Lin Julie, Ost David E
Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Curr Opin Pulm Med. 2021 Jul 1;27(4):229-239. doi: 10.1097/MCP.0000000000000782.
Robotic bronchoscopy is the newest advanced diagnostic bronchoscopy technology for biopsying peripheral pulmonary lesions; sensitivity for malignancy is currently suboptimal using modalities, such as radial endobronchial ultrasound or electromagnetic navigational bronchoscopy. We review the pitfalls of prior methods and the technological advancements with robotic bronchoscopy.
The contributors to reduced diagnostic sensitivity with current approaches include limitations in: navigation to the target, confirmation once the target is reached, and tissue acquisition. CT to body divergence with virtual reality methods, such as with electromagnetic navigation, potential false-positive confirmation with radial endobronchial ultrasound because of intraprocedural induced atelectasis, and lack of bronchoscopic and instrument maneuverability are all limitations to improving sensitivity. Robotic bronchoscopy enhances navigation through target pathway selection, allows for further reach in the distal airways, and improves tissue acquisition with more flexible and maneuverable biopsy instruments but lacks a high-fidelity target confirmation system.
Robotic bronchoscopy shows promise in biopsying peripheral lesions. Current published studies focus on diagnostic yield with robotic bronchoscopy. Future studies with long-term follow-up will be needed to assess diagnostic sensitivity for lung cancer and if robotic bronchoscopy is superior to other advanced diagnostic bronchoscopic techniques for peripheral pulmonary lesions.
机器人支气管镜检查是用于对周围肺部病变进行活检的最新先进诊断支气管镜技术;目前,使用诸如径向支气管内超声或电磁导航支气管镜等方式,对恶性肿瘤的敏感性欠佳。我们回顾了先前方法的缺陷以及机器人支气管镜检查的技术进展。
当前方法导致诊断敏感性降低的因素包括以下方面的局限性:导航至目标、到达目标后的确认以及组织获取。虚拟现实方法(如电磁导航)中CT与身体的偏差、因术中诱导肺不张导致径向支气管内超声出现潜在假阳性确认,以及支气管镜和器械的可操作性不足,都是提高敏感性的限制因素。机器人支气管镜检查通过目标路径选择增强了导航功能,能够进一步深入远端气道,并使用更灵活且可操作的活检器械改善了组织获取,但缺乏高保真的目标确认系统。
机器人支气管镜检查在对周围病变进行活检方面显示出前景。目前已发表的研究集中于机器人支气管镜检查的诊断率。需要进行长期随访的未来研究,以评估对肺癌的诊断敏感性,以及机器人支气管镜检查对于周围肺部病变是否优于其他先进的诊断支气管镜技术。