Palazzo J P, Duray P H
Department of Pathology, Yale University School of Medicine, New Haven.
J Cutan Pathol. 1988 Jun;15(3):166-70. doi: 10.1111/j.1600-0560.1988.tb00537.x.
Agminated, or grouped Spitz nevi are a curious expression of nevomelanocytic growth; and represent an uncommon manifestation of these nevi. We encountered an example of agminated Spitz nevi present at birth, which showed progression and rapid growth over months. All showed histologic Spitz nevus features. Avidin-biotin immunohistochemical techniques using anti S-100 protein, neuron-specific enolase (NSE), and melanoma-specific monoclonal antibody, HMB-45 labelled the nevi as follows: diffuse S-100 and NSE staining in most and HMB-45 positivity in sporadic cells deep in the dermis. HMB-45 reactivity occurred in both spindle cells and epithelioid forms.
聚合性或成簇状的斯皮茨痣是黑素细胞性生长的一种奇特表现；是这些痣的一种不常见表现形式。我们遇到了一例出生时即存在的聚合性斯皮茨痣，其在数月内出现进展且快速生长。所有病例均显示出组织学上斯皮茨痣的特征。使用抗S - 100蛋白、神经元特异性烯醇化酶（NSE）以及黑色素瘤特异性单克隆抗体HMB - 45的抗生物素蛋白 - 生物素免疫组化技术对这些痣的标记结果如下：大多数痣呈弥漫性S - 100和NSE染色，真皮深层散在细胞呈HMB - 45阳性。HMB - 45反应性在梭形细胞和上皮样细胞形态中均有出现。
