Lu Qiongyu, Cai Ping, Yu Yan, Liu Ziting, Chen Guona, Zeng Zhao
Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology of Jiangsu Province, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
Autoimmunity. 2021 Aug;54(5):294-302. doi: 10.1080/08916934.2021.1925885. Epub 2021 May 11.
Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Here, we analysed the landscape of Sema4D expression and its prognostic value in the cancer genome atlas pan-cancer as well as the correlation between Sema4D and immune cell infiltration by Tumour Immune Estimation Resource and Gene Expression Profiling interactive analysis online tools. Results showed that a higher Sema4D expression was significantly correlated with a favourable overall survival in diverse solid tumours including bladder cancer (Hazards Ratio (HR)=0.68, = .0095), kidney renal clear cell carcinoma (HR = 0.61, = .0016), melanoma (HR = 0.58, = 6.6e-05) and thymoma (HR = 0.1, = .011). Interestingly, Sema4D expression has positive correlation with various tumour infiltrating immune cells and immune cell biomarkers in these tumours. These results suggest that Sema4D could be a prospective biomarker for calculating hazard ratio of tumour patients and their tumour immune infiltration levels.
信号素4D（Sema4D）是免疫信号素家族的成员之一，在免疫调节、骨吸收和神经系统中发挥着关键作用。它还参与血管生成和肿瘤进展。然而，关于Sema4D表达与肿瘤免疫浸润或临床结局之间相关性的系统性研究仍然有限。在此，我们通过肿瘤免疫评估资源（Tumour Immune Estimation Resource）和基因表达谱交互式分析在线工具，分析了癌症基因组图谱泛癌中Sema4D的表达情况及其预后价值，以及Sema4D与免疫细胞浸润之间的相关性。结果显示，在包括膀胱癌（风险比（HR）=0.68，P = 0.0095）、肾透明细胞癌（HR = 0.61，P = 0.0016）、黑色素瘤（HR = 0.58，P = 6.6×10⁻⁵）和胸腺瘤（HR = 0.1，P = 0.011）在内的多种实体瘤中，较高的Sema4D表达与良好的总生存期显著相关。有趣 的是，在这些肿瘤中，Sema4D表达与各种肿瘤浸润免疫细胞和免疫细胞生物标志物呈正相关。这些结果表明，Sema4D可能是计算肿瘤患者风险比及其肿瘤免疫浸润水平的一个有前景的生物标志物。
