Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.
Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany.
Disabil Rehabil. 2022 Aug;44(17):4813-4820. doi: 10.1080/09638288.2021.1921861. Epub 2021 May 11.
Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.
Previous intervention (IG, = 10; 58.7 ± 8.4yrs) and control group (CG, = 9; 58.8 ± 6.6yrs) were asked for follow-up examinations 12 (T12) and 24 months (T24) after cessation of the supervised training (POST). Medical history, mental well-being, performance and immunological variables were analyzed with respect to intervention start (PRE).
IG maximum oxygen consumption (⩒O) 12%-improved POST ( = 0.05) and declined to baseline values T24, while CG ⩒O increased 12% T24 ( = 0.01). IG strength (1RM) increased 31% POST ( < 0.001) and remained above baseline level T24 ( = 0.003), whereas CG 1RM slightly improved T24 (+19%, = 0.034). IG Anxiety and Depression decreased POST and did not change until T24. IG C-reactive protein decreased POST and increased to pre-exercise levels T24. CG immunological/inflammatory/life quality markers did not change.
Six weeks of HIT/HIRT by breast cancer patients can induce similar beneficial effects like two years of convalescence, but outcomes were unstable and showed a fast backslide in aerobic capacity, activity level and in pro-inflammatory state within 12 months.IMPLICATIONS FOR REHABILITATIONHigh-intensity interval endurance and strength training (HIT/HIRT) for female breast cancer patients was shown to improve psychological well-being and performance, but long-term effects/adherence are unknown.Significant backslides in aerobic capacity, activity level as well as in the pro-inflammatory response after one and two years are observed and should be monitored.Continuous supervision and/or support of breast cancer patients before, during, and after medical care due to poor training adherence when voluntarily executed is recommended.
此前我们证实了为期六周的高强度间歇耐力和力量训练（HIT/HIRT）联合方案对非转移性乳腺癌女性患者的可行性，该方案可改善心理幸福感和运动表现。现在我们报告 24 个月随访的结果。
我们要求之前的干预组（IG，n=10；58.7±8.4 岁）和对照组（CG，n=9；58.8±6.6 岁）在监督训练停止后 12（T12）和 24 个月（T24）时进行随访检查。对 IG 和 CG 于干预开始前（PRE）、干预后（POST）和 T24 时的医学史、心理健康、运动表现和免疫变量进行分析。
IG 最大耗氧量（⩒O）在 POST 时改善了 12%（ = 0.05），并在 T24 时降至基线值，而 CG 的 ⩒O 在 T24 时增加了 12%（ = 0.01）。IG 的力量（1RM）在 POST 时增加了 31%（ < 0.001），并在 T24 时仍保持在基线以上（ = 0.003），而 CG 的 1RM 在 T24 时略有改善（+19%， = 0.034）。IG 的焦虑和抑郁在 POST 时下降，直到 T24 时才恢复。IG 的 C 反应蛋白在 POST 时下降，并在 T24 时恢复到运动前水平。CG 的免疫/炎症/生活质量标志物没有变化。
六周的 HIT/HIRT 可使乳腺癌患者产生类似的有益效果，如同两年的康复期，但结果不稳定，在 12 个月内，有氧能力、活动水平和促炎状态的快速恢复。
高强度间歇耐力和力量训练（HIT/HIRT）对女性乳腺癌患者的心理幸福感和运动表现有改善作用，但长期效果/依从性尚不清楚。
在一年和两年后观察到有氧能力、活动水平和促炎反应的显著反弹，应进行监测。
由于乳腺癌患者在医疗护理前、中、后缺乏训练依从性，建议在这期间对其进行持续监督和/或支持。
