Hassan Eman, Nagui Rizk Dalia, Aly Nourhan M, El Chazli Yasmine
Department of Pediatrics, Hematology and Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Paediatric Haematology Department, Birmingham Children's Hospital, Birmingham, United Kingdom.
Pediatr Hematol Oncol. 2021 Nov;38(8):683-694. doi: 10.1080/08880018.2021.1922559. Epub 2021 May 11.
Since the World Health Organization declared the COVID-19 pandemic in March 2020, the strain on healthcare services affected patients suffering from various comorbidities and added to the psychological burden. The study aimed to assess the health-related quality of life (HRQoL) and anxiety levels of pediatric Hematology/Oncology patients during the COVID19 pandemic and evaluate the association between anxiety levels and physical, emotional, and social aspects of HRQoL. A cross-sectional study was conducted on 292 children between 2.5 - 13 years with chronic hematological/oncological disorders. Pediatric Quality of Life Generic Core Scale and Spence Children's Anxiety Scale were used for assessment of HRQoL and anxiety, respectively. Linear regression was performed to assess the association between background and COVID-19 related factors with anxiety level. Multivariate Analysis of Variance (MANOVA) was performed to assess the association between the three HRQoL dimensions with child anxiety and different independent variables. Transfusion-dependent patients had lower anxiety levels than patients receiving chemotherapy (B=-14.45, 95% CI=-21.94,-6.95).Children who were aware of the pandemic had lower anxiety scores than those who were not, while those suffering from canceled clinic days had higher anxiety levels (B=-8.66,95% CI=-14.86,-2.45, and B = 7.33,95% CI =1.22,13.45, respectively). Anxiety significantly reduced the three HRQoL domains (B=-0.36, 95% CI=-0.47, -0.24 for physical functioning, B=-0.45, 95% CI =-0.56, -0.33 for social functioning and B=-0.50, 95% CI=-0.63,-0.38 for emotional functioning). This study highlights the effect of the pandemic on the anxiety level and hence the HRQoL of chronic hematological/oncological pediatric patients for guiding policies and interventions to maintain their psychological well-being.
自世界卫生组织于2020年3月宣布新型冠状病毒肺炎大流行以来，医疗服务面临的压力影响了患有各种合并症的患者，并加重了他们的心理负担。该研究旨在评估新型冠状病毒肺炎大流行期间儿科血液学/肿瘤学患者的健康相关生活质量（HRQoL）和焦虑水平，并评估焦虑水平与HRQoL的身体、情感和社会方面之间的关联。对292名年龄在2.5至13岁之间患有慢性血液学/肿瘤学疾病的儿童进行了一项横断面研究。分别使用儿童生活质量通用核心量表和斯彭斯儿童焦虑量表来评估HRQoL和焦虑。进行线性回归以评估背景因素和与新型冠状病毒肺炎相关的因素与焦虑水平之间的关联。进行多变量方差分析（MANOVA）以评估HRQoL的三个维度与儿童焦虑及不同自变量之间的关联。依赖输血的患者焦虑水平低于接受化疗的患者（B=-14.45，95%置信区间=-21.94，-6.95）。知晓大流行的儿童焦虑得分低于不知晓的儿童，而门诊日被取消的儿童焦虑水平较高（B=-8.66，95%置信区间=-14.86，-2.45，以及B = 7.33，95%置信区间 =1.22，13.45）。焦虑显著降低了HRQoL的三个领域（身体功能方面B=-0.36，95%置信区间=-0.47，-0.24；社会功能方面B=-0.45，95%置信区间 =-0.56，-0.33；情感功能方面B=-0.50，95%置信区间=-0.63，-0.38）。本研究强调了大流行对慢性血液学/肿瘤学儿科患者焦虑水平以及HRQoL的影响，可为维持其心理健康的政策和干预措施提供指导。
