姑息治疗中使用止吐药导致QTc延长的风险：一项叙述性综述。

The Risk of QTc Prolongation with Antiemetics in the Palliative Care Setting: A Narrative Review.

作者信息

Gavioli Elizabeth M, Guardado Nerli, Haniff Farah, Deiab Nouran, Vider Etty

机构信息

Elizabeth M. Gavioli, PharmD., Nerli Guardado, BA, Farah Haniff, BS, Nouran Deiab, BPS, and Etty Vider, PharmD, are with Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.

出版信息

J Pain Palliat Care Pharmacother. 2021 Jun;35(2):125-135. doi: 10.1080/15360288.2021.1900491. Epub 2021 May 11.

DOI:10.1080/15360288.2021.1900491

PMID:33974499

Abstract

Nausea and vomiting are common within the palliative care population. Antiemetic agents may help control symptoms, but may also place patients at risk for QTc prolongation. This article reviews pharmacotherapy agents including anticholinergics, antihistamines, antidopaminergics, 5-HT3 receptor antagonists, dronabinol, and medical marijuana and their associated risk of QTc prolongation. A clinical treatment pathway is provided to help guide clinicians in choosing the most appropriate antiemetic based upon patient specific factors for QTc prolongation.

摘要

恶心和呕吐在姑息治疗人群中很常见。止吐药可能有助于控制症状，但也可能使患者面临QTc延长的风险。本文综述了包括抗胆碱能药、抗组胺药、抗多巴胺能药、5-羟色胺3受体拮抗剂、屈大麻酚和医用大麻在内的药物治疗药物及其相关的QTc延长风险。提供了一种临床治疗途径，以帮助指导临床医生根据患者特定的QTc延长因素选择最合适的止吐药。