Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Skin Res Technol. 2021 Nov;27(6):1029-1034. doi: 10.1111/srt.13053. Epub 2021 May 11.
The goal of this study was evaluation of the skin biophysical properties in early patch/plaque stage of mycosis fungoides (MF) and its comparison with uninvolved skin in order to gain a better understanding of the pathogenesis of diseases.
The stratum corneum hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, R5), thickness, and echo density of epidermis and dermis were measured on lesions of 21 patients and compared with controls (average measures of uninvolved perilesional and symmetrical skins) by paired sample t test.
Stratum corneum hydration (P < 0.001) and echo density of dermis (P = 0.044) were significantly lower, whereas pH (P-value = 0.007), erythema (P < 0.001), and melanin content (P = 0.007) were significantly higher in lesions. There was not any significant difference in TEWL, friction index, sebum, temperature, R0, R2, R5, thickness of epidermis and dermis, and echo density of epidermis between lesions and normal skin.
Parapsoriasis/MF lesions are specified by a set of certain changes in biophysical properties which are mainly correlated with histological changes. These sets of alterations may help in noninvasive, early diagnosis of parapsoriasis/MF.
本研究旨在评估蕈样肉芽肿（MF）早期斑片/斑块期的皮肤生物物理特性，并与未受累皮肤进行比较，以便更好地了解疾病的发病机制。
对 21 例患者的皮损进行表皮和真皮的角质层含水量、经皮水分丢失（TEWL）、表面摩擦、pH 值、皮脂、黑色素、红斑、温度、弹性参数（R0、R2、R5）、厚度和回声密度的测量，并通过配对样本 t 检验与对照组（未受累皮损周围和对称皮肤的平均测量值）进行比较。
皮损的角质层含水量（P<0.001）和真皮回声密度（P=0.044）显著降低，而 pH 值（P 值=0.007）、红斑（P<0.001）和黑色素含量（P=0.007）显著升高。皮损与正常皮肤之间的 TEWL、摩擦指数、皮脂、温度、R0、R2、R5、表皮和真皮厚度以及表皮回声密度无显著差异。
蕈样肉芽肿皮损具有一组特定的生物物理特性变化，主要与组织学变化相关。这些变化组可能有助于非侵入性、早期诊断蕈样肉芽肿。
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