肿瘤内细菌在黑色素瘤中产生一类新的治疗相关肿瘤抗原。
Intratumoral bacteria generate a new class of therapeutically relevant tumor antigens in melanoma.
机构信息
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Department of Medicine, University of California San Diego, La Jolla, CA, USA.
出版信息
Cancer Cell. 2021 May 10;39(5):601-603. doi: 10.1016/j.ccell.2021.04.008.
PMID:33974857
Abstract
The functional repertoire of intratumoral microorganisms and their local effects on the host remain poorly characterized. By revealing potentially immunogenic bacterial peptides on melanoma cells, a Nature paper provides evidence that intratumoral bacteria can directly modulate antitumor immune responses, and it details a new class of therapeutically relevant, non-human tumor antigens.
摘要
肿瘤内微生物的功能谱及其对宿主的局部影响仍知之甚少。通过揭示黑色素瘤细胞上潜在的免疫原性细菌肽，一篇《自然》杂志的论文提供了证据，表明肿瘤内细菌可以直接调节抗肿瘤免疫反应，并且详细介绍了一类新的具有治疗意义的非人类肿瘤抗原。
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