Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Cancer Cell. 2021 May 10;39(5):601-603. doi: 10.1016/j.ccell.2021.04.008.
The functional repertoire of intratumoral microorganisms and their local effects on the host remain poorly characterized. By revealing potentially immunogenic bacterial peptides on melanoma cells, a Nature paper provides evidence that intratumoral bacteria can directly modulate antitumor immune responses, and it details a new class of therapeutically relevant, non-human tumor antigens.
肿瘤内微生物的功能谱及其对宿主的局部影响仍知之甚少。通过揭示黑色素瘤细胞上潜在的免疫原性细菌肽，一篇《自然》杂志的论文提供了证据，表明肿瘤内细菌可以直接调节抗肿瘤免疫反应，并且详细介绍了一类新的具有治疗意义的非人类肿瘤抗原。
