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内镜下治疗高流量前颅底脑脊液漏的“降落伞”技术。

The "Parachute" Technique for the Endoscopic Repair of High-Flow Anterior Skull-Base CSF Leaks.

机构信息

Department of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Medical-Surgical Physiopathology and Transplantation, University of Milan, Milan, Italy.

Department of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

出版信息

World Neurosurg. 2021 Jul;151:e880-e887. doi: 10.1016/j.wneu.2021.05.006. Epub 2021 May 8.

Abstract

OBJECTIVE

This study aims to assess the feasibility and reliability of our endoscopic trans-nasal technique for the repair of cribriform and sellar high-flow cerebrospinal fluid (CSF) leaks.

METHODS

A comparison between patients suffering from high-flow rhinorrhea and treated through a free grafting endoscopic technique or the "parachute" technique, our nasal packing proposal, was performed.

RESULTS

Thirty-three patients were included. The mean age was 52 years (range: 36-68 years). The etiology of the CSF leaks was iatrogenic in 16 cases (48.5%), traumatic in 5 cases (15.2%), spontaneous in 11 cases (33.3%), and related to anterior skull base tumors in 1 case (3%). The bone defect affected the sphenoidal sinus in 20 cases (60.6%), the cribriform plate of the ethmoid in 10 cases (30.3%), and both the sphenoid and ethmoid in 3 cases (9.1%). The mean size of bone defects was 8.5 ± 3.9 mm. The median follow-up was 28 (64) months. A CSF leak recurrence occurred in no cases treated with the parachute technique and in 3 cases that underwent conventional endoscopic treatments. The CSF leak recurrences were associated with 2 iatrogenic and 1 post-traumatic fistula. All the CSF leak recurrences underwent the parachute technique, not showing second recurrences.

CONCLUSIONS

Our results suggest that the parachute technique is simple, safe, and effective. We recommend it as an alternative treatment to vascular flaps for the treatment of high-flow and recurrent fistulas.

摘要

目的

本研究旨在评估我们经鼻内镜治疗颅底筛板和鞍区高流量脑脊液(CSF)漏的可行性和可靠性。

方法

对接受高流量鼻漏治疗的患者进行分组,比较采用游离移植物内镜技术或“降落伞”技术(我们的鼻腔填塞方案)的患者。

结果

共纳入 33 例患者。患者平均年龄为 52 岁(范围:36-68 岁)。CSF 漏的病因包括医源性 16 例(48.5%)、创伤性 5 例(15.2%)、自发性 11 例(33.3%)和与前颅底肿瘤相关 1 例(3%)。骨缺损累及蝶窦 20 例(60.6%)、筛骨板 10 例(30.3%)、蝶窦和筛骨均累及 3 例(9.1%)。骨缺损平均大小为 8.5±3.9mm。中位随访时间为 28(64)个月。采用“降落伞”技术治疗的患者无一例出现 CSF 漏复发,而采用传统内镜治疗的患者中有 3 例复发。CSF 漏复发与 2 例医源性和 1 例创伤性瘘管有关。所有 CSF 漏复发患者均采用“降落伞”技术治疗,未出现再次复发。

结论

我们的研究结果表明,“降落伞”技术简单、安全、有效。我们推荐该技术作为治疗高流量和复发性瘘管的血管皮瓣替代治疗方法。

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