Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
J Chromatogr A. 2021 Jul 5;1648:462187. doi: 10.1016/j.chroma.2021.462187. Epub 2021 Apr 26.
A novel polymer-based weak cation exchanger (WCX) for ion chromatography has been described. It was prepared by grafting tert-butyl acrylate and maleic anhydride onto the surface of poly(glycidyl methacrylate-divinylbenzene) microspheres via atom transfer radical polymerization, followed by hydrolytic treatment to produce acrylic and maleic acid groups. The obtained WCX showed better separation and higher selectivity for model cations relative to solely acrylic or maleic acid. Simultaneous separation of alkali and alkaline earth cations (including NH) was achieved in a single isocratic run under suppressed mode, and ion exchange was found to dominate the separation process. Its utility was demonstrated for determination of several cations in a beer sample and the recovery was ranging from 98.4 to 109.9%.
一种新型聚合物基弱阳离子交换剂（WCX）已被描述。它是通过原子转移自由基聚合将叔丁基丙烯酸酯和马来酸酐接枝到聚（甲基丙烯酸缩水甘油酯-二乙烯基苯）微球表面上制备的，然后进行水解处理以产生丙烯酸和马来酸基团。与仅含丙烯酸或马来酸的 WCX 相比，所得到的 WCX 对模型阳离子具有更好的分离和更高的选择性。在抑制模式下，通过单次等度运行即可实现碱金属和碱土金属阳离子（包括 NH）的同时分离，并且发现离子交换是分离过程的主要因素。它已被用于测定啤酒样品中的几种阳离子，回收率在 98.4%至 109.9%之间。
