Department of Psychiatry and Yale Child Study Center, Yale University School of Medicine, New Haven, CT, United States.
Biological Psychiatry Laboratory and Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Psychiatry Res. 2021 Jun;300:113853. doi: 10.1016/j.psychres.2021.113853. Epub 2021 Mar 4.
Obsessive-compulsive disorder (OCD) affects approximately one person in 40 and causes substantial suffering. Evidence-based treatments can benefit many; however, optimal treatment can be difficult to access. Diagnosis is frequently delayed, and pharmacological and psychotherapeutic interventions often fail to follow evidence-based guidelines. To ameliorate this distressing situation, the International OCD Accreditation Task Force of the Canadian Institute for Obsessive-Compulsive Disorders has developed knowledge and competency standards for specialized treatments for OCD through the lifespan. These are foundational to evidence-based practice and will form the basis for upcoming ATF development of certification/accreditation programs. Here, we present specialty standards for the pharmacological treatment of adult OCD. We emphasize the importance of integrating pharmacotherapy with clear diagnosis, appreciation of complicating factors, and evidence-based cognitive behavioral therapy. Clear evidence exists to inform first- and second-line pharmacological treatments. In disease refractory to these initial efforts, multiple strategies have been investigated, but the evidence is more equivocal. These standards summarize this limited evidence to give the specialist practitioner a solid basis on which to make difficult decisions in complex cases. It is hoped that further research will lead to development of a clear, multi-step treatment algorithm to support each step in clinical decision-making.
强迫症(OCD)影响大约每 40 人中就有 1 人,给患者带来了巨大的痛苦。循证治疗可以使许多人受益;然而,最佳治疗方法可能难以实现。诊断经常被延迟,药物和心理治疗干预往往不符合循证指南。为了改善这种令人痛苦的情况,加拿大强迫症研究所在国际强迫症认证工作组的努力下,制定了针对终生强迫症的专门治疗的知识和能力标准。这些标准是循证实践的基础,并将为即将到来的认证工作组制定认证/认证计划奠定基础。在这里,我们提出了成人强迫症药物治疗的专业标准。我们强调将药物治疗与明确的诊断、对复杂因素的理解以及循证认知行为疗法相结合的重要性。有明确的证据表明,一线和二线药物治疗是有效的。对于这些初始治疗无效的疾病,已经研究了多种策略,但证据更具争议性。这些标准总结了有限的证据,为专业医生在复杂病例中做出艰难决策提供了坚实的基础。希望进一步的研究能够制定出一个清晰的、多步骤的治疗算法,以支持临床决策的每一个步骤。