Department of Neurology, Danish Dementia Research Centre (DDRC), Copenhagen University Hospital, Rigshospitalet, Denmark.
Department of Neurology, Danish Dementia Research Centre (DDRC), Copenhagen University Hospital, Rigshospitalet, Denmark.
EBioMedicine. 2021 May;67:103361. doi: 10.1016/j.ebiom.2021.103361. Epub 2021 May 8.
The pathological changes in Alzheimer's Disease (AD) and other neurodegenerative disorders begin decades prior to their clinical expression. However, the clinical diagnosis of neurodegenerative dementias is not straightforward. Lactoferrin is an iron-binding, antimicrobial glycoprotein with a plethora of functions, including acting as an important immune modulator and by having a bacteriocidic effect. Two previous studies indicated that salivary lactoferrin could differentiate between neurodegenerative dementias.
A total of 222 cerebrospinal fluid (CSF) and saliva samples from a consecutive, mixed memory clinic population were analysed for lactoferrin. In addition, the association between lactoferrin in CSF and saliva and the concentration of tau, phosphorylated tau (p-tau) and amyloid 1-42 (Aβ) in CSF were addressed.
CSF lactoferrin was assessed for the first time in a cohort of patients with neurodegenerative dementias. No significant differences were found in the levels of CSF or saliva lactoferrin between the diagnostic groups. In addition, no significant relationships were found between lactoferrin levels and tau, p-tau and Aβ, respectively.
Neither CSF nor saliva lactoferrin could differentiate between neurodegenerative dementias in this study.
阿尔茨海默病（AD）和其他神经退行性疾病的病理变化早在其临床表达前几十年就开始了。然而，神经退行性痴呆症的临床诊断并不简单。乳铁蛋白是一种含铁的、抗菌糖蛋白，具有多种功能，包括作为重要的免疫调节剂和具有杀菌作用。之前的两项研究表明，唾液乳铁蛋白可以区分神经退行性痴呆症。
对连续的混合记忆诊所人群的 222 份脑脊液 (CSF) 和唾液样本进行了乳铁蛋白分析。此外，还研究了 CSF 和唾液中乳铁蛋白与 CSF 中 tau、磷酸化 tau (p-tau) 和淀粉样蛋白 1-42 (Aβ) 浓度之间的关联。
首次在神经退行性痴呆症患者队列中评估 CSF 乳铁蛋白。在诊断组之间，CSF 或唾液乳铁蛋白水平没有差异。此外，乳铁蛋白水平与 tau、p-tau 和 Aβ 之间也没有显著关系。
在本研究中，CSF 和唾液乳铁蛋白均不能区分神经退行性痴呆症。
