Cikrt M, Mravcová A, Malátová I, Bencko V
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1988;32(1):17-29.
The exposure of man to isolated toxic agent in the environment is rather a rare phenomenon. Therefore the study of a combined action of toxic substances is of increasing importance. The excretion and distribution of 74As (500 micrograms As.kg-1 b.wt.; Na74AsO2) and 75Se (525 micrograms Se.kg-1 b.wt.; Na275SeO3) was studied in rats after their separate and simultaneous i.v. injections. After simultaneous administration urinary as well as biliary excretion of 75Se and urinary excretion of 74As was increased in comparison with that in animals injected the radionuclides separately. Simultaneous administration of 74As and 75Se decreased concentration of 75Se in liver and increased concentration of 74As in kidney. In rats drinking water containing As (III) (0.66 mmol.l-1), Se(IV) (0.13 mmol.l-1) or combination As(III) + Se(IV) (at the same concentrations) for 7 or 28 days was studied the excretion and distribution of 74As and 75Se after their simultaneous i.v. injection (at the same concentrations and labelled compounds as mentioned above). The pretreatment with one element or with the combination of both elements significantly modified the distribution and excretion of subsequently administered 74As and 75Se.
人类在环境中接触单一有毒物质的情况相当罕见。因此，研究有毒物质的联合作用变得越来越重要。在大鼠静脉内分别注射和同时注射74As（500微克砷·千克-1体重；Na74AsO2）和75Se（525微克硒·千克-1体重；Na275SeO3）后，对它们的排泄和分布情况进行了研究。与分别注射放射性核素的动物相比，同时给药后，75Se的尿排泄和胆汁排泄以及74As的尿排泄均增加。同时给予74As和75Se会降低肝脏中75Se的浓度，并增加肾脏中74As的浓度。在大鼠饮用含砷（III）（0.66毫摩尔·升-1）、硒（IV）（0.13毫摩尔·升-1）或砷（III）+硒（IV）组合（相同浓度）的水7天或28天后，研究了同时静脉注射74As和75Se（与上述相同浓度和标记化合物）后的排泄和分布情况。用一种元素或两种元素的组合进行预处理显著改变了随后给予的74As和75Se的分布和排泄。
