Department for internal medicine, Faculty of Medicine, University of Niš, Niš, Serbia.
Clinic for lung diseases, Clinical center Niš, Niš, Serbia.
Pharmacology. 2021;106(7-8):400-408. doi: 10.1159/000515935. Epub 2021 May 11.
Antioxidants such as lycopene (LCP) and caffeic acid phenethyl ester (CAPE) represent ideal molecules for the treatment of different reactive oxygen species (ROS) associated disorders. Cisplatin is a chemotherapeutic agent, causing an increase in ROS and DNA damage, with numerous side effects, which include lung toxicity. In the presents study, we evaluated and mutually compared the potential of LCP and CAPE in preventing cisplatin-induced rat lung damage.
The study was done using pathohistological analysis and a panel of biochemical parameters that reflect lung oxidative tissue damage, inflammation, and apoptosis.
The obtained results suggest that cisplatin (10 mg/kg) causes significant disturbances in the lung tissue morphology, followed by an increase in lipid peroxidization and protein modification. Also, a pronounced inflammatory response and cell apoptosis cascade activation was noted. Both LCP and CAPE were able to mitigate the changes, to a different extent, in oxidative damage and apoptosis progression induced by cisplatin. However, they both had limited effect on inflammation since they only prevented an increase in myeloperoxidase activity but had not been able to prevent the NO generation.
It is hard to be exact in saying whether LCP or CAPE is better in preventing cis-platin-induced lung damage since they obviously possess different mechanisms of action.
抗氧化剂，如番茄红素（LCP）和咖啡酸苯乙酯（CAPE），是治疗与不同活性氧（ROS）相关疾病的理想分子。顺铂是一种化疗药物，会导致 ROS 和 DNA 损伤增加，并伴有许多副作用，包括肺毒性。在本研究中，我们评估并相互比较了 LCP 和 CAPE 预防顺铂诱导的大鼠肺损伤的潜力。
该研究采用组织病理学分析和一系列反映肺氧化组织损伤、炎症和细胞凋亡的生化参数进行。
结果表明，顺铂（10mg/kg）导致肺组织形态显著紊乱，随后脂质过氧化和蛋白质修饰增加。此外，还观察到明显的炎症反应和细胞凋亡级联激活。LCP 和 CAPE 均能在不同程度上减轻顺铂诱导的氧化损伤和细胞凋亡进展的变化。然而，它们对炎症的影响有限，因为它们只能防止髓过氧化物酶活性的增加，但不能防止 NO 的产生。
很难确切地说 LCP 或 CAPE 哪个更能预防顺铂引起的肺损伤，因为它们显然具有不同的作用机制。
