Wilson M, Fried J, McQuay R M, Sulzer A J
Am J Trop Med Hyg. 1977 Nov;26(6 Pt 1):1159-63. doi: 10.4269/ajtmh.1977.26.1159.
Sera from patients with a variety of infections were used to compare the sensitivity and specificity of the complement fixation (CF) and the indirect immunofluorescence (IIF) tests for schistosomiasis. Adult antigens were used in both tests. The sensitivities of the IIF and CF tests were 95% and 69%, respectively; the specificities were 98% and 100%, respectively. There was no statistical difference between the number of positive reactors among those individuals with no detectable helminth infection and those infected with helminths other than schistosomes. Infected people native to endemic areas had lower reactivity in both tests than did infected U.S. citizens who resided in endemic areas for only a few years. We concluded that the IIF test with adult antigen was more sensitive than and as specific as the CF test; therefore, the IIF test is the procedure of choice for routine diagnostic serology of schistosomiasis.
使用患有各种感染的患者血清来比较补体结合试验（CF）和间接免疫荧光试验（IIF）对血吸虫病检测的敏感性和特异性。两种试验均使用成虫抗原。IIF试验和CF试验的敏感性分别为95%和69%；特异性分别为98%和100%。在未检测到蠕虫感染的个体与感染了除血吸虫之外其他蠕虫的个体中，阳性反应者的数量没有统计学差异。来自流行地区的感染人群在两种试验中的反应性均低于仅在流行地区居住几年的美国感染公民。我们得出结论，使用成虫抗原的IIF试验比CF试验更敏感且特异性相同；因此，IIF试验是血吸虫病常规诊断血清学的首选方法。
