Department of Pharmacology, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Indian J Pharmacol. 2021 Jan-Feb;53(1):31-38. doi: 10.4103/ijp.IJP_233_18.
Studies have shown that there is a critical time period to start hormone therapy after the loss of ovarian function during menopause. The length of estrogen deprivation may evolve different pathophysiological manifestations.
The aim of the present study was to investigate behavioral, biochemical, and molecular alterations at different time points after surgical menopause with an aim and identify various pathophysiological targets to exploit "window of opportunity" and to design newer therapeutic modalities for menopause-associated neurobehavioral and vascular deficits.
Bilateral ovariectomy was performed to induce surgical menopause and estrogen deficiency state. Menopause-associated neuronal and vascular dysfunctions were noted after 1, 2, and 3 months of the study.
Neuronal and vascular endothelial dysfunction post ovariectomy revealed that behavioral, biochemical, molecular, and vascular endothelial dysfunction appeared after 1 month of ovariectomy except hyperglycemia, which occurs after 3 months.
Time-response studies measuring behavioral, biochemical, and molecular markers at various time points after ovariectomy reveal that there is a fast onset of neuronal and vascular complications, but the duration of insulin resistance is a relatively late phenomenon.
研究表明，在绝经期间卵巢功能丧失后，开始激素治疗有一个关键时期。雌激素缺乏的时间可能会出现不同的病理生理表现。
本研究旨在探讨手术绝经后不同时间点的行为、生化和分子改变，旨在确定各种病理生理靶点，以利用“机会之窗”，并为与绝经相关的神经行为和血管缺陷设计新的治疗方法。
双侧卵巢切除术用于诱导手术绝经和雌激素缺乏状态。在研究开始后 1、2 和 3 个月观察到绝经相关的神经元和血管功能障碍。
卵巢切除术后的神经元和血管内皮功能障碍表明，行为、生化、分子和血管内皮功能障碍在卵巢切除后 1 个月出现，除了 3 个月后出现的高血糖。
在卵巢切除后不同时间点测量行为、生化和分子标志物的时间反应研究表明，神经元和血管并发症的发生很快，但胰岛素抵抗的持续时间是一个相对较晚的现象。
