Laboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Mexico City, Mexico.
J Psychopharmacol. 2011 Oct;25(10):1365-77. doi: 10.1177/0269881111408456. Epub 2011 Sep 2.
Controversial results related to effectiveness of estrogen replacement therapy (ERT) to alleviate depression are frequently reported. The discrepancies could be related to (a) time when ERT is initiated after the beginning of menopause and/or (b) type of estrogen used. Furthermore, estrogens modulate the antidepressant effect of different compounds; therefore, the effectiveness of antidepressant drugs could also depend on the menopausal status. The aim of the present study was to analyze whether the time after estrogen decline can influence antidepressant-like effects of two estrogens and/or two antidepressants. Thus, the antidepressant-like actions of 17β-estradiol (E(2)), 17α-ethynyl-estradiol (EE(2)), fluoxetine (FLX) and desipramine (DMI) were studied at different periods (1, 3 and 12 weeks) after ovariectomy (OVX), using the forced swimming test (FST). Results showed that OVX increased depressive-like behavior only 1 week after OVX. The antidepressant-like actions of E(2), but not those of EE(2), were cancelled 12 weeks after OVX. Conversely, antidepressant-like actions of FLX and DMI were observed at 1, 3 and 12 weeks after OVX. In conclusion, while the antidepressant-like effects of estrogens depended on the time at which treatment is initiated after OVX as well as on the estrogenic compound used, antidepressant-like effects of FLX and DMI were not blocked by OVX.
经常有报道称，雌激素替代疗法（ERT）缓解抑郁的效果存在争议。这种差异可能与（a）ERT 开始的时间，即绝经后开始的时间，和/或（b）使用的雌激素类型有关。此外，雌激素可以调节不同化合物的抗抑郁作用；因此，抗抑郁药物的有效性也可能取决于绝经状态。本研究旨在分析雌激素水平下降后时间是否会影响两种雌激素和/或两种抗抑郁药的抗抑郁样作用。因此，使用强迫游泳试验（FST），在卵巢切除（OVX）后不同时间（1、3 和 12 周）研究了 17β-雌二醇（E（2））、17α-乙炔雌二醇（EE（2））、氟西汀（FLX）和去甲丙咪嗪（DMI）的抗抑郁样作用。结果表明，OVX 仅在 OVX 后 1 周增加了抑郁样行为。E（2）的抗抑郁样作用，但不是 EE（2）的抗抑郁样作用，在 OVX 后 12 周被取消。相反，FLX 和 DMI 的抗抑郁样作用在 OVX 后 1、3 和 12 周均观察到。总之，虽然雌激素的抗抑郁样作用取决于 OVX 后开始治疗的时间以及所使用的雌激素化合物，但 OVX 并没有阻断 FLX 和 DMI 的抗抑郁样作用。
