Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Can Respir J. 2021 Apr 22;2021:6657724. doi: 10.1155/2021/6657724. eCollection 2021.
This study aimed to investigate the effects of continuous positive airway pressure (CPAP) on the electroencephalographic (EEG) characteristics of patients with primary central sleep apnea syndrome (CSAS). Nine patients with primary CSAS were enrolled in this study. The raw sleep EEG data were analyzed based on two main factors: fractal dimension (FD) and zero-crossing rate of detrended FD. Additionally, conventional EEG spectral analysis in the delta, theta, alpha, and beta bands was conducted using a fast Fourier transform. The FD in patients with primary CSAS who underwent CPAP treatment was significantly decreased during nonrapid eye movement (NREM) sleep but increased during rapid eye movement (REM) sleep ( < 0.05). Regarding the EEG spectral analysis, the alpha power increased, while the delta/alpha ratio decreased during REM sleep in patients with CSAS ( < 0.05). In conclusion, CPAP treatment can reduce FD in NREM sleep and increase FD during REM sleep in patients with primary CSAS. FD may be used as a new biomarker of EEG stability and improvement in brain function after CPAP treatment for primary CSAS.
本研究旨在探讨持续气道正压通气（CPAP）对原发性中枢性睡眠呼吸暂停综合征（CSAS）患者脑电图（EEG）特征的影响。本研究纳入了 9 例原发性 CSAS 患者。根据分形维数（FD）和去趋势 FD 的零交叉率这两个主要因素对原始睡眠 EEG 数据进行分析。此外，还采用快速傅里叶变换对 delta、theta、alpha 和 beta 波段进行了常规 EEG 频谱分析。CPAP 治疗后原发性 CSAS 患者的 FD 在非快速眼动（NREM）睡眠时显著降低，但在快速眼动（REM）睡眠时增加（<0.05）。关于 EEG 频谱分析，CSAS 患者在 REM 睡眠期间 alpha 功率增加，而 delta/alpha 比值降低（<0.05）。综上所述，CPAP 治疗可降低原发性 CSAS 患者 NREM 睡眠时的 FD，并增加 REM 睡眠时的 FD。FD 可作为 CPAP 治疗原发性 CSAS 后脑功能稳定性和改善的新的 EEG 标志物。
