Yiğman Metin, Tangal Semih, Haliloğlu Ahmet Hakan, Çağlar Gamze Sinem
Ufuk University Faculty of Medicine, Department of Urology, Ankara, Turkey.
Ufuk University Faculty of Medicine, Department of Obtetrics and Gynecology, Ankara, Turkey.
Cent European J Urol. 2021;74(1):95-98. doi: 10.5173/ceju.2021.0284.R1. Epub 2021 Mar 11.
The 46,XX male syndrome is a rare disorder of sex development and has two different forms, depending on the sex-determining region's presence on the Y chromosome (SRY) gene. The SRY positive 46,XX males are usually diagnosed during infertility workup. We evaluated the erectile function of 46,XX SRY positive males and compared it with healthy males.
Ten patients with azoospermia and 46,XX SRY positive disorder who referred to a urology clinic with infertility were analyzed retrospectively. Controls were chosen from healthy males at similar ages. The physical examination was performed, and serum hormones were obtained at admission. The clinical assessment of erectile dysfunction was evaluated by the International Index of Erectile Function (IIEF) questionnaire.
There was no statistically significant difference between the two groups in terms of age, serum prolactin, luteinizing hormone (LH) levels and IIEF scores (P >0.05). In 46,XX males, serum follicle-stimulating hormone (FSH) levels were significantly higher, and total testosterone levels and testicular volumes were found to be significantly lower when compared to controls (p <0.001, p <0.05, p <0.01, respectively).
This study indicates that these males' erectile function is similar to those of 46,XY males.
46,XX男性综合征是一种罕见的性发育障碍，根据Y染色体性别决定区域（SRY）基因的存在情况有两种不同形式。SRY阳性的46,XX男性通常在不育症检查过程中被诊断出来。我们评估了46,XX SRY阳性男性的勃起功能，并将其与健康男性进行了比较。
回顾性分析了10例因不育症到泌尿外科就诊的无精子症且患有46,XX SRY阳性疾病的患者。对照组从年龄相仿的健康男性中选取。入院时进行体格检查并获取血清激素水平。通过国际勃起功能指数（IIEF）问卷对勃起功能障碍进行临床评估。
两组在年龄、血清催乳素、黄体生成素（LH）水平和IIEF评分方面无统计学显著差异（P>0.05）。与对照组相比，46,XX男性的血清促卵泡生成素（FSH）水平显著更高，总睾酮水平和睾丸体积显著更低（分别为p<0.001、p<0.05、p<0.01）。
本研究表明这些男性的勃起功能与46,XY男性相似。
