Woodhams Louise, Sim Tin Fei, Chalmers Leanne, Yeap Bu, Green Daniel, Schlaich Markus, Schultz Carl, Hillis Graham
Curtin Medical School, Curtin University of Technology, Perth, Western Australia, Australia.
Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.
PeerJ. 2021 Apr 19;9:e11070. doi: 10.7717/peerj.11070. eCollection 2021.
The global prevalence of diabetic kidney disease is rapidly accelerating due to an increasing number of people living with type 2 diabetes. It has become a significant global problem, increasing human and financial pressures on already overburdened healthcare systems. Interest in diabetic kidney disease has increased over the last decade and progress has been made in determining the pathogenic mechanisms and patient-related factors involved in the development and pathogenesis of this disease. A greater understanding of these factors will catalyse the development of novel treatments and influence current practice. This review summarises the latest evidence for the factors involved in the development and progression of diabetic kidney disease, which will inform better management strategies targeting such factors to improve therapeutic outcomes in patients living with diabetes.
由于2型糖尿病患者人数不断增加，全球糖尿病肾病的患病率正在迅速上升。它已成为一个重大的全球性问题，给本已不堪重负的医疗系统带来了越来越大的人力和财力压力。在过去十年中，人们对糖尿病肾病的关注度有所提高，在确定该疾病发生发展的致病机制和患者相关因素方面取得了进展。对这些因素的更深入了解将推动新型治疗方法的开发，并影响当前的临床实践。本综述总结了糖尿病肾病发生发展相关因素的最新证据，这将为针对这些因素制定更好的管理策略提供依据，以改善糖尿病患者的治疗效果。
