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胆囊管黏液性囊性肿瘤:一种罕见实体的罕见部位。

Mucinous Cystic Neoplasm of the Cystic Duct: A Rare Location of a Rare Entity.

作者信息

Caldwell Nicholas J, Farhat Ilham, Boukhar Sarag

机构信息

Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.

Pathology, University of Iowa Hospitals and Clinics, Iowa City, USA.

出版信息

Cureus. 2021 Apr 9;13(4):e14377. doi: 10.7759/cureus.14377.

DOI:10.7759/cureus.14377
PMID:33976995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8106810/
Abstract

Mucinous cystic neoplasms (MCNs) are uncommon cystic lesions that arise in the liver and biliary system (MCN-LBS) and the pancreas (MCN-P) and rarely arise from the extrahepatic biliary system. Histologically, these lesions are defined by the presence of variably mucin-producing epithelium with ovarian-like, hypercellular mesenchymal stroma. Herein, we present a case of extrahepatic MCN-LBS in a 51-year-old woman. This lesion arose from the cystic duct and was removed via laparoscopic cholecystectomy. Histologic examination confirmed the diagnosis. To our knowledge, this is the third case report of an MCN-LBS arising from the cystic duct in the English literature. In this article, we review clinical and histologic characteristics of MCNs and present two other reports of MCN-LBS of the cystic duct.

摘要

黏液性囊性肿瘤(MCNs)是一种罕见的囊性病变,可发生于肝脏和胆道系统(MCN-LBS)以及胰腺(MCN-P),极少起源于肝外胆道系统。从组织学上看,这些病变的特征是存在产生不同量黏液的上皮细胞以及类似卵巢的、细胞丰富的间充质基质。在此,我们报告一例51岁女性的肝外MCN-LBS病例。该病变起源于胆囊管,通过腹腔镜胆囊切除术切除。组织学检查确诊了该诊断。据我们所知,这是英文文献中第三例关于起源于胆囊管的MCN-LBS的病例报告。在本文中,我们回顾了MCNs的临床和组织学特征,并呈现了另外两例胆囊管MCN-LBS的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/905050d8179f/cureus-0013-00000014377-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/f4c847348143/cureus-0013-00000014377-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/d1ee1457ab22/cureus-0013-00000014377-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/6180fef8842b/cureus-0013-00000014377-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/2a476c440220/cureus-0013-00000014377-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/905050d8179f/cureus-0013-00000014377-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/f4c847348143/cureus-0013-00000014377-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/d1ee1457ab22/cureus-0013-00000014377-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/6180fef8842b/cureus-0013-00000014377-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/2a476c440220/cureus-0013-00000014377-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1117/8106810/905050d8179f/cureus-0013-00000014377-i05.jpg

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本文引用的文献

1
Hepatic Mucinous Cystic Neoplasm Versus Simple Biliary Cyst: Assessment of Distinguishing Imaging Features Using CT and MRI.肝黏液性囊性肿瘤与单纯性胆管囊肿的 CT 和 MRI 鉴别诊断特征评估。
AJR Am J Roentgenol. 2021 Feb;216(2):403-411. doi: 10.2214/AJR.20.22768. Epub 2020 Dec 23.
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A Mucinous Cystic Neoplasm Originating from the Gallbladder: A Case Report and Literature Review.一例起源于胆囊的黏液性囊性肿瘤:病例报告及文献复习
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Mucinous cystic neoplasm of the liver with biliary communication: an exception to the current classification.
具有胆管相通的肝脏黏液性囊性肿瘤:当前分类的一个例外情况
BMJ Case Rep. 2019 Jan 10;12(1):bcr-2018-227063. doi: 10.1136/bcr-2018-227063.
4
Mucinous Cystic Neoplasm of the Liver or Intraductal Papillary Mucinous Neoplasm of the Bile Duct? A Case Report and a Review of Literature.肝黏液性囊腺瘤或胆管内乳头状黏液性肿瘤?病例报告及文献复习。
Ann Hepatol. 2018 May-June;17(3):519-524. doi: 10.5604/01.3001.0011.7397. Epub 2018 Apr 9.
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A case of mucinous cystic neoplasm of the gallbladder.一例胆囊黏液性囊性肿瘤。
Clin J Gastroenterol. 2018 Oct;11(5):428-432. doi: 10.1007/s12328-018-0850-8. Epub 2018 Mar 13.
6
Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression.由丰富黏液上皮衬覆的黏液性囊性肿瘤常伴有KRAS突变和恶性进展。
Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178.
7
Hepatobiliary Mucinous Cystic Neoplasms With Ovarian Type Stroma (So-Called "Hepatobiliary Cystadenoma/Cystadenocarcinoma"): Clinicopathologic Analysis of 36 Cases Illustrates Rarity of Carcinomatous Change.伴有卵巢型间质的肝胆黏液性囊性肿瘤(所谓的“肝胆囊腺瘤/囊腺癌”):36例临床病理分析显示癌变罕见
Am J Surg Pathol. 2018 Jan;42(1):95-102. doi: 10.1097/PAS.0000000000000963.
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Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression.肝和胰腺黏液性囊性肿瘤:KRAS 驱动突变与疾病进展的关系。
Histopathology. 2017 Oct;71(4):591-600. doi: 10.1111/his.13271. Epub 2017 Aug 2.
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Nonmucinous Biliary Epithelium Is a Frequent Finding and Is Often the Predominant Epithelial Type in Mucinous Cystic Neoplasms of the Pancreas and Liver.非黏液性胆管上皮是常见表现,且往往是胰腺和肝脏黏液性囊性肿瘤中主要的上皮类型。
Am J Surg Pathol. 2017 Jan;41(1):116-120. doi: 10.1097/PAS.0000000000000745.
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Mucinous Cystic Neoplasm of the Liver Masquerading as an Echinococcal Cyst: Radiologic-pathologic Differential of Complex Cystic Liver Lesions.伪装成棘球蚴囊肿的肝脏黏液性囊性肿瘤:复杂囊性肝病变的放射学-病理学鉴别诊断
J Clin Imaging Sci. 2016 Mar 30;6:12. doi: 10.4103/2156-7514.179426. eCollection 2016.