Hu Yuanyuan, Luo Honggen, Tu Xiangtu, Xue Han, Jin Hongwei, Liu Yunkui, Zhou Bingwei
College of Chemical Engineering Zhejiang University of Technology, Hangzhou, 310014, China.
Chem Commun (Camb). 2021 May 11;57(38):4686-4689. doi: 10.1039/d1cc01233a.
In previous literature, tert-cyclobutanols are widely studied for C-C bond activation exclusively leading to the formation of ordinary γ-substituted ketones. Herein, we first report a nickel-catalyzed cine-arylation of tert-cyclobutanols with indoles to access β-aryl ketones with an unusual site-selectivity at the C3-position of tert-cyclobutanols. The reaction features earth-abundant nickel catalysis, excellent regioselectivity, high atom-economy, and broad substrate scope.
在以往的文献中，叔丁基环丁醇主要因其C-C键活化仅生成普通的γ-取代酮而受到广泛研究。在此，我们首次报道了镍催化叔丁基环丁醇与吲哚的烯丙基芳基化反应，以在叔丁基环丁醇的C3位获得具有不寻常位点选择性的β-芳基酮。该反应具有地球丰富的镍催化、优异的区域选择性、高原子经济性和广泛的底物范围。
