Institute for Glycomics, Griffith University Gold Coast Campus, Southport, Queensland, Australia.
Chem Commun (Camb). 2021 May 11;57(38):4666-4669. doi: 10.1039/d1cc01593a.
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.
我们确定取代稳定的多核铂配合物（PPC）TriplatinNC 是一种抗病毒药物，可以保护细胞免受肠道病毒 71 型和人类偏肺病毒感染。这种保护作用是通过与细胞表面糖胺聚糖形成加合物来实现的。我们的详细机制研究表明，TriplatinNC 通过保护细胞免受病毒攻击来阻止病毒进入，为金属保护抗病毒药物的开发开辟了新的方向。
