Doberczak T M, Shanzer S, Senie R T, Kandall S R
Department of Pediatrics, Beth Israel Medical Center, Mt. Sinai School of Medicine, New York, NY 10003.
J Pediatr. 1988 Aug;113(2):354-8. doi: 10.1016/s0022-3476(88)80283-x.
Thirty-nine infants with intrauterine exposure to cocaine were examined for neurologic and electroencephalographic (EEG) abnormalities. Of the 39 infants, 34 displayed central nervous system irritability, but only two of the infants required sedation. The EEGs were abnormal in 17 of 38 infants during the first week of life; abnormalities were characterized as showing central nervous system irritability. The EEG abnormalities could not be predicted on the basis of clinical neurologic dysfunction or perinatal variables. On follow-up, 9 of the 17 abnormal EEGs remained abnormal during the second week of life. One infant had an abnormal first EEG at 13 days of age. By 3 to 12 months of age, however, 9 of the 10 previously abnormal tracing had normalized and one is pending. These transient clinical and EEG abnormalities may be the result of changes in neurotransmitter availability and function.
对39名在子宫内接触过可卡因的婴儿进行了神经系统和脑电图（EEG）异常检查。在这39名婴儿中，34名表现出中枢神经系统易激惹，但只有两名婴儿需要镇静。在出生后的第一周，38名婴儿中有17名的脑电图异常；异常表现为中枢神经系统易激惹。脑电图异常无法根据临床神经功能障碍或围产期变量进行预测。在随访中，17名脑电图异常的婴儿中有9名在出生后的第二周仍异常。一名婴儿在13日龄时首次脑电图异常。然而，到3至12个月大时，之前10次异常记录中的9次已恢复正常，1次仍有待观察。这些短暂的临床和脑电图异常可能是神经递质可用性和功能变化的结果。
