Laboratory for Biomimetic Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia.
Org Biomol Chem. 2021 Jun 2;19(21):4637-4651. doi: 10.1039/d1ob00164g.
This review focuses on the synthesis of 3-hydroxyisoindolinones, and their application as substrates in stereoselective catalytic transformations reported from 2010 to date. These compounds have attracted much attention among synthetic chemists, as they are integral structural parts of a number of natural products and biologically active compounds. The first part of this review covers methods based on electrochemical, photochemical, and thermal reactions for the synthesis of 3-hydroxyisoindolinones. The second part focuses on their employment as substrates in transition metal-catalyzed and organocatalyzed stereoselective transformations for the preparation of chiral 3-substituted isoindolinone derivatives.
这篇综述重点介绍了 3-羟基异吲哚啉酮的合成方法，以及它们作为底物在 2010 年至今报道的立体选择性催化转化中的应用。这些化合物在合成化学家之间引起了广泛关注，因为它们是许多天然产物和生物活性化合物的重要结构部分。本文综述的第一部分涵盖了基于电化学、光化学和热反应的方法，用于合成 3-羟基异吲哚啉酮。第二部分则侧重于它们作为底物在过渡金属催化和有机催化的立体选择性转化中的应用，用于制备手性 3-取代异吲哚啉酮衍生物。
