The Relationship between Serum Uric Acid Level and Liver Function in Patients with Hepatitis B in China.

BACKGROUND

To explore the correlation between serum uric acid (UA) level and liver function indexes in patients with hepatitis B, so as to provide guidance for the prediction and treatment of liver function damage in patients with hepatitis B.

METHODS

Four hundred and eighty-five patients with hepatitis B were selected as the case group and 312 patients without hepatitis B matched in the same period as the control group. The difference of blood UA level in each group was analyzed, and the correlation between UA and ALT, AST and CREA in each group was analyzed.

RESULTS

UA in the hepatitis B group was significantly higher than that in non-hepatitis B group, and the difference was statistically significant (p = 0.000). Correlation analysis showed that UA was correlated with ALT in non-hepatitis B group (p < 0.001), while UA was significantly correlated with ALT and AST in hepatitis B group (p < 0.001). Correlation analysis showed that UA was correlated with ALT in male group, but not in female group. The results of logistic multivariate regression analysis showed that the increase of serum UA level was a risk factor for liver function damage in patients with hepatitis B.

CONCLUSIONS

The level of UA in patients with hepatitis B was significantly higher than that in patients without hepatitis B. The level of UA was positively correlated with the damage of liver function indexes. The correlation between UA and liver function indexes was stronger in males than that in females.