通过芳基重氮盐、DABSO和五氟苯酚的铜催化反应一锅法合成五氟苯磺酸酯
One-Pot Synthesis of Pentafluorophenyl Sulfonic Esters via Copper-Catalyzed Reaction of Aryl Diazonium Salts, DABSO, and Pentafluorophenol.
作者信息
Idris Muhammad Aliyu, Lee Sunwoo
机构信息
Department of Chemistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
出版信息
Org Lett. 2021 Jun 18;23(12):4516-4520. doi: 10.1021/acs.orglett.1c01056. Epub 2021 May 12.
Pentafluorophenyl (PFP) sulfonic esters were synthesized via a copper-catalyzed one-pot multicomponent reaction of aryl diazonium tetrafluoroborate, DABSO (DABCO·(SO)), and pentafluorophenol. The reaction system provided the desired pentafluorophenyl sulfonic esters in good yields and exhibited excellent functional group tolerance. In addition, the generated PFP sulfonic esters were successfully applied in Sonogashira, Suzuki, Chan-Evans-Lam, and decarboxylative coupling reactions.
通过芳基四氟硼酸重氮盐、DABSO（DABCO·(SO)）和五氟苯酚的铜催化一锅多组分反应合成了五氟苯基（PFP）磺酸酯。该反应体系以良好的产率提供了所需的五氟苯基磺酸酯，并且表现出优异的官能团耐受性。此外，生成的PFP磺酸酯成功应用于Sonogashira、Suzuki、Chan-Evans-Lam和脱羧偶联反应。
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