Koletzko B, Tangermann R, von Kries R, Stannigel H, Willberg B, Radde I, Schmidt E
Pediatrics Department, University of Düsseldorf, F.R.G.
J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):548-53. doi: 10.1097/00005176-198807000-00012.
Supplementation of milk formulae with calcium salts is recommended for low birth weight infants. We observed a serious complication of calcium administration in too high a dosage. Three premature infants (birth weight 1,080-1,900 g and gestational age 28-35 weeks) developed an obstruction of the distal ileum during the second week of life, leading to multiple bowel perforations and development of septic peritonitis in two cases. All three patients required surgical removal of a bolus blocking the intestinal lumen. Analysis of the bolus material from one infant indicated that the formation of soaps from calcium and long-chain fatty acids had caused the obstruction. All three infants had been fed a formula for premature infants with the addition of a recently introduced commercial mineral supplement, resulting in a very high calcium concentration of the feed (40.6 mmol/L). Simulation of syringe feeding demonstrated that even higher calcium concentrations could occur in milk portions containing sedimented calcium compounds.
建议给低体重出生婴儿的配方奶补充钙盐。我们观察到钙剂量过高会引发严重并发症。三名早产儿（出生体重1080 - 1900克，胎龄28 - 35周）在出生后第二周出现回肠末端梗阻，导致两例出现多处肠穿孔和化脓性腹膜炎。所有三名患者都需要手术取出阻塞肠腔的团块。对一名婴儿的团块物质分析表明，钙与长链脂肪酸形成肥皂导致了梗阻。这三名婴儿均喂食了添加了最近推出的商业矿物质补充剂的早产儿配方奶，导致奶液中钙浓度非常高（40.6毫摩尔/升）。模拟注射器喂食表明，含有沉淀钙化合物的奶液部分钙浓度可能更高。
