Vasan Eye Care, Mysore, Karnataka, India.
B. P. Koirala Centre for Ophthalmic Studies (BPKLCOS), Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Nepal J Ophthalmol. 2020 Jul;12(24):252-261. doi: 10.3126/nepjoph.v12i2.26483.
Penetrating keratoplasty has become one of the most commonly performed transplant procedures where full thickness diseased host corneal tissue is replaced with healthy donor corneal tissue. Aims of penetrating keratoplasty include improvement in visual acuity, removal of infectious load, alleviate pain or even to simply save the anatomy of the eye. Visual improvement and removal of infection is the prime objective of majority of corneal grafts. The objective of the study was to evaluate various current indications of penetrating keratoplasty in central Nepal and its difference from the developed world.
A hospital based study of 36 patients who underwent penetrating keratoplasty between January 2014 and June 2015 was carried out at B.P. Koirala Centre for ophthalmic studies. Following clinical examination and investigations, surgical intervention was done when required. The patient data were recorded and followed up. Indication for surgery, investigations and demographic profile were assessed.
Mean recipient age was 46.56 years (+/- 16.02 years). The male: female ratio was 1.57:1. The most common indication for penetrating keratoplasty was infectious keratitis (44.44%), followed by corneal opacity or scarring (30.56 %), re-grafts (13.89%),bullous keratopathy (2.78%), keratoconus (2.78%) and others (2.78%) Introduction: Penetrating keratoplasty has become one of the most commonly performed transplant procedures where full thickness diseased host corneal tissue is replaced with healthy donor corneal tissue. Aims of penetrating keratoplasty include improvement in visual acuity, removal of infectious load, alleviate pain or even to simply save the anatomy of the eye. Visual improvement and removal of infection is the prime objective of majority of corneal grafts. The objective of the study was to evaluate various current indications of penetrating keratoplasty in central Nepal and its difference from the developed world.
A hospital based study of 36 patients who underwent penetrating keratoplasty between January 2014 and June 2015 was carried out at B.P. Koirala Centre for ophthalmic studies. Following clinical examination and investigations, surgical intervention was done when required. The patient data were recorded and followed up. Indication for surgery, investigations and demographic profile were assessed.
Mean recipient age was 46.56 years (+/- 16.02 years). The male: female ratio was 1.57:1. The most common indication for penetrating keratoplasty was infectious keratitis (44.44%), followed by corneal opacity or scarring (30.56 %), re-grafts (13.89%),bullous keratopathy (2.78%), keratoconus (2.78%) and others (2.78%) Conclusion: Though corneal diseases and indications for transplant surgery in developing countries are different from those in the western world, penetrating keratoplasty has emerged as one of the most successful way to reduce corneal blindness and to restore vision.
Though corneal diseases and indications for transplant surgery in developing countries are different from those in the western world, penetrating keratoplasty has emerged as one of the most successful way to reduce corneal blindness and to restore vision.
穿透性角膜移植术已成为最常施行的移植手术之一，在该手术中，用健康供体的角膜组织替换全层病变的宿主角膜组织。穿透性角膜移植术的目的包括提高视力、清除感染负荷、缓解疼痛，甚至只是为了保存眼球的解剖结构。大多数角膜移植的主要目标是提高视力和清除感染。本研究的目的是评估尼泊尔中部目前穿透性角膜移植的各种适应证，并与发达国家进行比较。
在 BP Koirala 眼科研究中心，对 2014 年 1 月至 2015 年 6 月期间接受穿透性角膜移植术的 36 例患者进行了一项基于医院的研究。在进行临床检查和检查后，根据需要进行手术干预。记录患者数据并进行随访。评估手术适应证、检查和人口统计学特征。
受者平均年龄为 46.56 岁（+/-16.02 岁）。男女比例为 1.57:1。穿透性角膜移植最常见的适应证是感染性角膜炎（44.44%），其次是角膜混浊或瘢痕（30.56%）、再次移植（13.89%）、大泡性角膜病变（2.78%）、圆锥角膜（2.78%）和其他（2.78%）。
尽管发展中国家的角膜疾病和移植适应证与西方国家不同，但穿透性角膜移植已成为减少角膜盲和恢复视力的最成功方法之一。
