Plasma 11-deoxycortisol and cortisol following dexamethasone in psychiatric patients.
作者信息
Joyce P R, Elder P A, Clifford J C, Brinded P J, Donald R A
机构信息
Affective Disorders Unit, Sunnyside Hospital, Christchurch, New Zealand.
出版信息
J Psychiatr Res. 1988;22(1):29-33. doi: 10.1016/0022-3956(88)90025-8.
PMID:3397907
Abstract
As it has been suggested that calculating the ratio of cortisol to its biosynthetic precursor, 11-deoxycortisol, may enhance the sensitivity of the dexamethasone suppression test (DST) for depression, cortisol and 11-deoxycortisol were measured in 90 subjects undergoing this test. Among these subjects, post-dexamethasone cortisol and 11-deoxycortisol levels were significantly correlated (r = 0.65, P less than 0.001) and evaluating the ratio of cortisol to 11-deoxycortisol decreased rather than enhanced sensitivity of the DST.
摘要
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