State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.
Org Lett. 2021 May 21;23(10):3991-3996. doi: 10.1021/acs.orglett.1c01191. Epub 2021 May 12.
An NHC-catalyzed atroposelective reaction between ynals and urazoles is disclosed. The reaction establishes a chiral C-N axis via an atroposelective [3 + 2] annulation/desymmetrization process. Our reaction allows efficient access to axially chiral and heteroatom-rich urazole derivatives with potential applications in bioactive molecules and catalysis.
一种 NHC 催化的 ynals 和尿嘧啶之间的对映选择性反应被揭示。该反应通过对映选择性[3+2]环加成/去对称化过程建立了手性 C-N 轴。我们的反应可以有效地获得具有潜在应用于生物活性分子和催化的轴手性和杂原子丰富的尿嘧啶衍生物。
