Orthopedics Department, Affiliated Tongji Hospital of Huazhong University of Science and Technology, Wuhan City, Hubei Province, 430030, China.
Department of Biomedical Engineering.
J Wound Care. 2021 May 2;30(5):350-370. doi: 10.12968/jowc.2021.30.5.350.
The burden of the management of problematic skin wounds characterised by a compromised skin barrier is growing rapidly. Almost six million patients are affected in the US alone, with an estimated market of $25 billion annually. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. Novel strategies are needed for faster healing by reducing infection, moisturising the wound, stimulating the healing mechanisms, speeding up wound closure and reducing scar formation.
A systematic review of qualitative studies was conducted on the recent perspectives of nanotechnology in burn wounds management. Pubmed, Scopus, EMBASE, CINAHL and PsychINFO databases were all systematically searched. Authors independently rated the reporting of the qualitative studies included. A comprehensive literature search was conducted covering various resources up to 2018-2019. Traditional techniques aim to simply cover the wound without playing any active role in wound healing. However, nanotechnology-based solutions are being used to create multipurpose biomaterials, not only for regeneration and repair, but also for on-demand delivery of specific molecules. The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue.
Nanotechnology-based therapy is in the forefront of next-generation therapy that is able to advance wound healing of hard-to-heal wounds. In this review, we will highlight the developed nanotechnology-based therapeutic agents and assess the viability and efficacy of each treatment. Herein we will explore the unmet needs and future directions of current technologies, while discussing promising strategies that can advance the wound-healing field.
具有受损皮肤屏障特征的问题皮肤伤口的管理负担正在迅速增加。仅在美国，就有近 600 万名患者受到影响，估计每年的市场规模为 250 亿美元。迫切需要有效的基于机制的治疗方法和更有效的药物输送系统。需要新的策略来通过减少感染、滋润伤口、刺激愈合机制、加速伤口闭合和减少疤痕形成来更快地愈合。
对纳米技术在烧伤伤口管理中的最新观点进行了系统的定性研究综述。对 Pubmed、Scopus、EMBASE、CINAHL 和 PsychINFO 数据库进行了系统检索。作者独立评估了纳入的定性研究报告。对 2018-2019 年期间的各种资源进行了全面的文献检索。传统技术旨在简单地覆盖伤口，而不在伤口愈合中发挥任何积极作用。然而，基于纳米技术的解决方案正被用于创建多功能生物材料，不仅用于再生和修复，还用于按需输送特定分子。非愈合伤口的慢性性质和相关并发症导致了基于纳米技术的治疗方法的出现，这些方法旨在促进愈合过程，并最终修复受损组织。
基于纳米技术的治疗是下一代治疗的前沿，能够促进难以愈合的伤口的愈合。在这篇综述中，我们将重点介绍开发的基于纳米技术的治疗剂，并评估每种治疗方法的可行性和疗效。在这里，我们将探讨当前技术的未满足需求和未来方向，同时讨论可以推进伤口愈合领域的有前途的策略。
