Singh G, Singh M M, Maitra S C, Elger W, Kalra V, Upadhyay S N, Chowdhury S R, Kamboj V P
Central Drug Research Institute, Lucknow, India.
J Reprod Fertil. 1988 May;83(1):73-83. doi: 10.1530/jrf.0.0830073.
RU-38486 or ZK-98734 treatment (3 mg/day, s.c.) to intact or hysterectomized adult female rats on Days 5-7 post coitum induced changes characteristic of luteolysis. Ultrastructurally, the luteal cells exhibited an extensive vacuolization of the cytoplasm and perinuclear areas, degeneration of mitochondrial cristae, massive accumulation of lipid droplets, increase in number of lysosome like granules and heterochromatinization of the nucleus. In general, RU-38486 induced more marked degeneration of the luteal cells than did ZK-98734. There was also a significant decrease in peripheral plasma progesterone concentrations in treated rats. We suggest that these antiprogestagens act via inhibition of luteal function in addition to their antagonism at the uterine progesterone receptor level.
在成年雌性大鼠交配后第5至7天，对完整或子宫切除的大鼠进行RU - 38486或ZK - 98734治疗（3毫克/天，皮下注射），可诱导黄体溶解的特征性变化。超微结构上，黄体细胞表现出细胞质和核周区域广泛空泡化、线粒体嵴退化、脂滴大量积累、溶酶体样颗粒数量增加以及细胞核异染色质化。总体而言，RU - 38486诱导的黄体细胞退化比ZK - 98734更明显。治疗大鼠外周血浆孕酮浓度也显著降低。我们认为，这些抗孕激素除了在子宫孕酮受体水平具有拮抗作用外，还通过抑制黄体功能发挥作用。
