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类风湿关节炎住院治疗与门诊治疗后的患者预后

Patient outcome following inpatient vs outpatient treatment of rheumatoid arthritis.

作者信息

Anderson R B, Needleman R D, Gatter R A, Andrews R P, Scarola J A

机构信息

Division of Rheumatology, Abington Memorial Hospital, PA 19001.

出版信息

J Rheumatol. 1988 Apr;15(4):556-60.

PMID:3397965
Abstract

To assess the short and longterm efficacy of intensive inpatient treatment of active rheumatoid arthritis (RA), 16 patients, the test group, admitted to a hospital based rheumatic disease unit (mean length of stay 12.4 days) were studied, using clinical and laboratory variables. The comparison group was similarly evaluated, using 10 outpatients with active RA to whom hospitalization was recommended, but refused by the patients. Both groups were studied intensively over a 12-week period. In addition, a 2-year followup was performed on 12 test group inpatients and 8 comparison group outpatients, using the same variables plus a functional status questionnaire. Health care costs were determined for both groups and corrected for a 1985 dollar value. The test group showed significant improvement in morning stiffness, pain, and joint score, whereas the comparison group improved only in pain score during the initial 12-week period. At 2 years, the test group and the comparison group showed significant improvement in morning stiffness, pain, grip strength, and joint score. The comparison group initially had a somewhat lower index of disease activity. The test group maintained their initial improvement and none required rehospitalization. Functional status scores were similar for both groups. Health care costs were initially higher for the test group ($5,065); followup care cost for the test group was $99 less/year than the comparison group over 2 years. Hospitalization on a rheumatic disease unit brought about prompt, sustained improvement in 2 weeks which required nearly 2 years to achieve in the comparison group. Such hospitalization of uncomplicated RA seems warranted to decrease disability and increase the quality of life.

摘要

为评估活动性类风湿关节炎(RA)强化住院治疗的短期和长期疗效,对收治于一家医院风湿病科的16例患者(试验组,平均住院时间12.4天)进行了研究,采用了临床和实验室变量。对照组采用10例活动性RA门诊患者进行类似评估,这些患者被建议住院,但患者拒绝了。两组均在12周期间进行了深入研究。此外,对试验组的12例住院患者和对照组的8例门诊患者进行了为期2年的随访,使用相同变量外加一份功能状态问卷。确定了两组的医疗保健费用,并校正为1985年的美元价值。试验组在晨僵、疼痛和关节评分方面有显著改善,而对照组在最初的12周期间仅疼痛评分有所改善。在2年时,试验组和对照组在晨僵、疼痛、握力和关节评分方面均有显著改善。对照组最初的疾病活动指数略低。试验组维持了最初的改善,且无人需要再次住院。两组的功能状态评分相似。试验组最初的医疗保健费用较高(5065美元);试验组的随访护理费用在2年期间每年比对照组少99美元。在风湿病科住院在2周内带来了迅速、持续的改善,而对照组则需要近2年才能实现。对于无并发症的RA患者,这种住院治疗似乎有助于减少残疾并提高生活质量。

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