Department of Psychology, Florida State University, 1107 West Call St, Tallahassee, FL 32304, United States.
Department of Psychology, Florida State University, 1107 West Call St, Tallahassee, FL 32304, United States; Department of Psychology, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany.
Psychiatry Res Neuroimaging. 2021 Jul 30;313:111298. doi: 10.1016/j.pscychresns.2021.111298. Epub 2021 May 2.
Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically to depressed participants with impaired mood reactivity.
The current study compared individuals diagnosed with current depressive disorder (n = 26) with healthy controls (n = 24) regarding brain responses to gain and loss trials in an fMRI version of the "Doors" choice-feedback task. Study aims were to examine reward-related brain activation in relation to depression, depressive subtypes, and course of depression.
Across the sample, participants showed a significant response to gain versus loss in left and right ventral striatum as well as medial and left lateral prefrontal cortex. Relative to controls, participants with current depression were characterized by blunted reactivity in left ventral striatum. Furthermore, activation in the left ventral striatum differentiated subgroups of depression with and without impaired mood reactivity. Finally, left striatal hypoactivation to reward predicted remission when controlling for current depressive symptomatology, albeit at a trend level.
Blunted reward-related activation in the left ventral striatum might be useful as a marker for depression subtype and may have the potential to predict future course of depression.
最近，人们努力对主要抑郁障碍的亚型进行分类，这些亚型的特征是不同的心理生理学指标，其中在赌博任务中观察到的与奖励相关的大脑激活减弱，被认为是与情绪反应受损的抑郁患者特别相关的特征。
本研究比较了当前患有抑郁障碍（n=26）的个体和健康对照组（n=24）在 fMRI 版“门”选择反馈任务中对收益和损失试验的大脑反应。研究目的是检查与抑郁、抑郁亚型和抑郁病程相关的奖励相关的大脑激活。
在整个样本中，参与者在左侧和右侧腹侧纹状体以及内侧和左侧外侧前额叶皮层中表现出对收益与损失的显著反应。与对照组相比，当前患有抑郁的参与者的左侧腹侧纹状体反应性减弱。此外，左侧腹侧纹状体的激活区分了具有和不具有情绪反应受损的抑郁亚组。最后，在控制当前抑郁症状的情况下，左侧纹状体对奖励的激活减弱可以预测缓解，尽管只是趋势水平。
左侧腹侧纹状体中与奖励相关的激活减弱可能是抑郁亚型的有用标志物，并且可能具有预测未来抑郁病程的潜力。
