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Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with L265P mutation.

作者信息

Dlouhy Ivan, Armengol Marc, Recasens-Zorzo Clara, Ribeiro Marcelo L, Pérez-Galán Patricia, Bosch Francesc, López-Guillermo Armando, Roué Gaël

机构信息

Department of Hematology, Hospital Clínic, BarceIona, Spain; Division of Hematology and Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona.

Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona.

出版信息

Haematologica. 2021 Oct 1;106(10):2749-2753. doi: 10.3324/haematol.2020.278258.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead8/8485659/45fc35d85e82/1062749.fig1.jpg

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本文引用的文献

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Molecular pathogenesis of germinal center-derived B cell lymphomas.
Immunol Rev. 2019 Mar;288(1):240-261. doi: 10.1111/imr.12745.
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Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.
Nat Med. 2018 May;24(5):679-690. doi: 10.1038/s41591-018-0016-8. Epub 2018 Apr 30.
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Treatment of Diffuse Large B-Cell Lymphoma.
J Clin Exp Hematop. 2016;56(2):79-88. doi: 10.3960/jslrt.56.79.
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B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.
Blood. 2016 Jun 2;127(22):2732-41. doi: 10.1182/blood-2015-11-684183. Epub 2016 Apr 5.
9
Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4.
Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50. doi: 10.1016/j.bmcl.2015.10.060. Epub 2015 Oct 23.
10
Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.
J Clin Invest. 2015 Mar 2;125(3):1081-97. doi: 10.1172/JCI75821. Epub 2015 Feb 2.

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