Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of CD18-Dependent Phagocytosis.

Chronic infection mysteriously occurs in the airways of patients with cystic fibrosis (CF), bronchiectasis (BE), and chronic obstructive pulmonary disease (COPD) in the absence of neutrophil dysfunction or neutropenia and is strongly associated with autoimmunity to bactericidal permeability-increasing protein (BPI). Here, we define a critical role for BPI in immunity against Wild type and BPI-deficient ( mice were infected with , and bacterial clearance, cell infiltrates, cytokine production, and phagocytosis were quantified. mice exhibited a decreased ability to clear in concert with increased neutrophil counts and cytokine release. neutrophils displayed decreased phagocytosis that was corrected by exogenous BPI . Exogenous BPI also enhanced clearance of in -/- mice by increasing uptake by neutrophils in a CD18-dependent manner. These data indicate that BPI plays an essential role in innate immunity against through its opsonic activity and suggest that perturbations in BPI levels or function may contribute to chronic lung infection with .