Mavligit G M, Charnsangavej C, Carrasco C H, Patt Y Z, Benjamin R S, Wallace S
Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston 77030.
JAMA. 1988 Aug 19;260(7):974-6.
Thirty patients with ocular melanoma metastatic to the liver were treated by hepatic arterial chemoembolization using an admixture of cisplatin and polyvinyl sponge. Tumor regression was complete in one patient and partial (greater than 50%) in 13 patients. The total response rate was 46%. The median survival for the entire group was 11 months (95% confidence interval, nine to 18 months). Treatment-related morbidity was short-lived and included primarily severe upper right quadrant abdominal pain, transient paralytic ileus, and nonicteric hepatitis. Hepatic arterial chemoembolization provided effective palliation, with good-quality survival among 46% of patients with ocular melanoma metastatic to the liver.
30例眼部黑色素瘤肝转移患者接受了肝动脉化疗栓塞治疗，使用顺铂和聚乙烯海绵的混合物。1例患者肿瘤完全消退，13例患者部分消退（大于50%）。总缓解率为46%。整个组的中位生存期为11个月（95%置信区间，9至18个月）。与治疗相关的发病率是短暂的，主要包括严重的右上腹疼痛、短暂性麻痹性肠梗阻和无黄疸型肝炎。肝动脉化疗栓塞提供了有效的姑息治疗，46%眼部黑色素瘤肝转移患者生存质量良好。
