Robinson Rachel, Lähdepuro Anna, Tuovinen Soile, Girchenko Polina, Rantalainen Ville, Heinonen Kati, Lahti Jari, Räikkönen Katri, Lahti-Pulkkinen Marius
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland.
National Institute for Health and Welfare, Helsinki, Finland.
Curr Hypertens Rep. 2021 May 13;23(5):30. doi: 10.1007/s11906-021-01141-w.
We review here recent original research and meta-analytic evidence on the associations of maternal hypertensive pregnancy disorders and mental and behavioral disorders in the offspring.
Seven meta-analyses and 11 of 16 original research studies published since 2015 showed significant associations between maternal hypertensive pregnancy disorders and offspring mental and behavioral disorders. Evidence was most consistent in meta-analyses and high-quality cohort studies. The associations, independent of familial confounding, were observed on different mental and behavioral disorders in childhood and schizophrenia in adulthood. Preterm birth and small-for-gestational age birth emerged as possible moderators and mediators of the associations. Cross-sectional and case-control studies yielded inconsistent findings, but had lower methodological quality. Accumulating evidence from methodologically sound studies shows that maternal hypertensive pregnancy disorders are associated with an increased risk of mental and behavioral disorders in the offspring in childhood. More studies on adult mental disorders are needed.
我们在此回顾近期关于孕产妇高血压妊娠疾病与后代精神和行为障碍之间关联的原创研究和荟萃分析证据。
自2015年以来发表的七项荟萃分析和16项原创研究中的11项表明，孕产妇高血压妊娠疾病与后代精神和行为障碍之间存在显著关联。证据在荟萃分析和高质量队列研究中最为一致。在独立于家族混杂因素的情况下，观察到了儿童期不同精神和行为障碍以及成年期精神分裂症之间的关联。早产和小于胎龄儿出生可能是这些关联的调节因素和中介因素。横断面研究和病例对照研究结果不一致，但方法学质量较低。来自方法学合理研究的证据不断积累表明，孕产妇高血压妊娠疾病与儿童期后代精神和行为障碍风险增加有关。需要更多关于成人精神障碍的研究。
