Radboud University Medical Center, Department of Obstetrics and Gynecology, P.O. Box 9101, Post 791, 6500 HB Nijmegen, The Netherlands.
Canisius-Wilhelmina Hospital, Department of Obstetrics and Gynecology, P.O. Box 9105, 6500 GS Nijmegen, The Netherlands.
Pregnancy Hypertens. 2020 Jul;21:200-202. doi: 10.1016/j.preghy.2020.06.006. Epub 2020 Jun 27.
This Dutch multicenter case-controlled study investigated whether cortisol concentrations and psychosocial stress during pregnancy differed between women with early-onset preeclampsia, late-onset preeclampsia, and uncomplicated pregnancies. Cortisol concentrations were analyzed in three hair segments representing the preconception period, first, and second trimester of pregnancy. Cortisol trajectories differed, with early-onset preeclampsia showing steeper increases in cortisol and higher cortisol concentrations during the second trimester. Reported anxiety in women with preeclampsia was higher compared to women with uncomplicated pregnancies. These results indicate that measures of cortisol and reported anxiety differ between early-onset, late-onset preeclampsia, and uncomplicated pregnancies.
这项荷兰多中心病例对照研究调查了早发型子痫前期、晚发型子痫前期和正常妊娠的孕妇在怀孕期间的皮质醇浓度和心理社会压力是否存在差异。在三个头发段中分析了皮质醇浓度，代表受孕前、第一和第二孕期。皮质醇轨迹不同，早发型子痫前期的皮质醇增加更为陡峭，第二孕期的皮质醇浓度更高。报告的子痫前期妇女的焦虑高于正常妊娠妇女。这些结果表明，早发型、晚发型子痫前期和正常妊娠之间的皮质醇和报告焦虑的测量值存在差异。
