Laboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Villeurbanne, France.
Anses, Maisons-Alfort Cedex, France.
Integr Environ Assess Manag. 2022 Jan;18(1):10-18. doi: 10.1002/ieam.4439. Epub 2021 Jun 1.
Today, only few ready-to-use and convenient decision-making tools are available in ecotoxicology concerning accumulation and effects of chemical substances on organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolism, mixtures, etc.). This paper presents new perspectives on the generic calculation of bioaccumulation metrics via the innovative web tool MOSAIC (http://mosaic.univ-lyon1.fr/bioacc). MOSAIC provides all kinds of bioaccumulation metrics associated with their uncertainty whatever the species-compound combination. MOSAIC expects accumulation-depuration data as inputs, even with complex exposure and clearance patterns, to quickly perform their relevant analysis. MOSAIC intends to facilitate the daily work of regulators, or any ecotoxicologist, who will freely benefit from a user-friendly online interface that automatically fits toxicokinetic models without need for users to invest in the technical aspects to get bioaccumulation metrics estimates. MOSAIC also provides all results in a fully transparent way to ensure reproducibility. Integr Environ Assess Manag 2022;18:10-18. © 2021 SETAC.
如今，在生态毒理学领域，针对已知复杂暴露情况（暴露途径、代谢、混合物等）下化学物质对生物体的积累和影响，仅有少数现成且方便的决策工具可用。本文提出了一种通过创新的网络工具 MOSAIC（http://mosaic.univ-lyon1.fr/bioacc）来计算生物累积指标的通用方法的新观点。MOSAIC 提供了各种与其不确定性相关的生物累积指标，无论物种-化合物组合如何。MOSAIC 期望以积累-排泄数据作为输入，即使暴露和清除模式复杂，也能快速进行相关分析。MOSAIC 旨在为监管机构或任何生态毒理学家提供便利，他们将可以自由受益于用户友好的在线界面，该界面可以自动拟合毒代动力学模型，而无需用户在技术方面进行投资，以获得生物累积指标的估计值。MOSAIC 还以完全透明的方式提供所有结果，以确保可重复性。综合环境评估与管理 2022；18:10-18. © 2021 SETAC.
