小分子治疗自身免疫和炎症性疾病的方法（第二部分）：核酸感应拮抗剂和抑制剂。
Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors.
机构信息
Department of Medicinal Chemistry, Roche Innovation Center Shanghai, Roche Pharma Research and Early Development, Shanghai 201203, China.
Department of Medicinal Chemistry, Roche Innovation Center Shanghai, Roche Pharma Research and Early Development, Shanghai 201203, China.
出版信息
Bioorg Med Chem Lett. 2021 Jul 15;44:128101. doi: 10.1016/j.bmcl.2021.128101. Epub 2021 May 10.
Nucleic acid sensing pathways play an important role in the innate immune system, protecting hosts against infections. However, a large body of evidence supports a close association between aberrant activation of those pathways and autoimmune and inflammatory diseases. Part II of the digest series on small molecule approaches to autoimmune and inflammatory diseases concentrates on recent advances with respect to small molecule antagonists or inhibitors of the nucleic acid sensing pathways, including endosomal TLRs, NLRP3 inflammasome and cGAS-STING.
核酸感应途径在先天免疫系统中起着重要作用，保护宿主免受感染。然而，大量证据表明，这些途径的异常激活与自身免疫和炎症性疾病密切相关。关于自身免疫和炎症性疾病的小分子方法的文摘系列的第二部分集中于核酸感应途径的小分子拮抗剂或抑制剂的最新进展，包括内体 TLR、NLRP3 炎性体和 cGAS-STING。
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