Department of Surgical Oncology, Ankara City Hospital, Ankara, Turkey
Department of Histology Embryology, Medical College, Ankara Yıldırım Beyazıt University, Ankara, Turkey
Turk J Med Sci. 2021 Aug 30;51(4):2213-2221. doi: 10.3906/sag-2010-270.
BACKGROUND/AIM: We aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received ısole hydrolyzed whey protein (IHWP) at different doses regularly and rats fed with only standard feed.
MATERIAL & METHODS: Total 24 rats were randomly divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Second group were given standard feed + daily 0.3 g/kg IHWP and rats in the third group standard feed + 0.5 g/kg IHWP for 12 weeks. Blood samples were collected from all rats before and after IHWP administration. All rats were then sacrificed, and thyroid tissues were histopathologically examined.
Interfollicular connective tissue areas and TSH (0.35–4.90 μIU/L) were higher in the control group compared to 3 cc IHWP and 5 cc IHWP groups, while thyroid hormone T4 (0.7–1.48 ng/dL), and thyroid hormone synthesis parameters including intrafollicular colloid amount, follicular diameter, and epithelial height were significantly higher in 3 cc and 5 cc IHWP groups compared to the control.
We think that regular daily use of IHWP may increase the synthesis of thyroid hormone due to its high amino acid content.
背景/目的：我们旨在研究定期给予不同剂量水解乳清蛋白（IHWP）的大鼠与仅给予标准饲料的大鼠之间 TSH、T3、T4 值和甲状腺组织的组织病理学评估是否存在显著差异。
总共 24 只大鼠被随机分为三组，每组 8 只。第一组给予标准饲料 12 周。第二组给予标准饲料+每日 0.3 g/kg IHWP，第三组给予标准饲料+0.5 g/kg IHWP 12 周。所有大鼠在给予 IHWP 前后均采集血样。所有大鼠随后被处死，并对甲状腺组织进行组织病理学检查。
与 3 cc IHWP 和 5 cc IHWP 组相比，对照组的滤泡间结缔组织面积和 TSH（0.35-4.90 μIU/L）较高，而甲状腺激素 T4（0.7-1.48 ng/dL）和甲状腺激素合成参数，包括滤泡内胶体量、滤泡直径和上皮高度在 3 cc 和 5 cc IHWP 组中显著高于对照组。
我们认为，由于 IHWP 具有较高的氨基酸含量，因此其日常定期使用可能会增加甲状腺激素的合成。
