Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Flinders University - College of Medicine and Public Health, Adelaide, South Australia, Australia.
Expert Rev Respir Med. 2021 Sep;15(9):1229-1238. doi: 10.1080/17476348.2021.1928496. Epub 2021 Jul 2.
: There is sparse literature evidence in the spirometric patterns of adult Indigenous Australians with and without chest computed tomography (CT)-proven chronic airway diseases (CADs).: Participants spirometry testing graded as acceptable for quality and had a chest CT scan showing radiographic evidence of CADs were included for analysis.: Of the 1350 spirometric tests performed between 2012 and 2020, a total of 212 patients with a mean age of 53 years and 54% females were eligible to be included. One-third (30%) had normal chest CT (without CADs), 35% had predominant COPD, 19% bronchiectasis and 16% combined COPD and bronchiectasis. Percentage predicted values for forced vital capacity (FVC) and forced expiratory volume in one second (FEV) both pre- and post- bronchodilator were significantly reduced for all participants - FVC: CT-normal 64%, 65%; COPD 58%, 62%; bronchiectasis 54%, 54%; combined COPD and bronchiectasis 50%, 53%. FEV: CT-normal 62%, 65%; COPD 46%, 49%; bronchiectasis 48%,51%; combined COPD and bronchiectasis 36%,40%. FEV/FVC was only reduced for CT abnormality patients - CT-normal 96%,98%; COPD 77%,77%; bronchiectasis 87%,89%; combined COPD and bronchiectasis 71%,72%.: Restrictive spirometric pattern is common and an obstructive pattern with COPD, in isolation or when COPD coexists with bronchiectasis.
成人澳大利亚原住民的肺功能模式,无论是否存在胸部计算机断层扫描 (CT) 证实的慢性气道疾病 (CAD),相关文献证据都很少。
参与者的肺功能测试质量分级为可接受,并进行了胸部 CT 扫描,显示 CAD 的放射影像学证据,被纳入分析。
在 2012 年至 2020 年间进行的 1350 次肺功能测试中,共有 212 名平均年龄为 53 岁、女性占 54%的患者符合入选条件。三分之一(30%)的患者胸部 CT 正常(无 CAD),35%的患者主要患有 COPD,19%的患者患有支气管扩张症,16%的患者同时患有 COPD 和支气管扩张症。所有参与者的用力肺活量 (FVC) 和一秒用力呼气量 (FEV) 的预计百分比值均显著降低,无论是否使用支气管扩张剂——FVC:CT 正常 64%,65%;COPD 58%,62%;支气管扩张症 54%,54%;COPD 和支气管扩张症合并症 50%,53%。FEV:CT 正常 62%,65%;COPD 46%,49%;支气管扩张症 48%,51%;COPD 和支气管扩张症合并症 36%,40%。仅 CT 异常患者的 FEV/FVC 降低——CT 正常 96%,98%;COPD 77%,77%;支气管扩张症 87%,89%;COPD 和支气管扩张症合并症 71%,72%。
限制性肺功能模式很常见,阻塞性模式以 COPD 为主,也可能单独存在,或与支气管扩张症同时存在。