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成人慢性气道疾病的澳大利亚原住民的肺功能模式与胸部计算机断层扫描的相关性的批判性分析。

Critical analysis of spirometric patterns in correlation to chest computed tomography among adult Indigenous Australians with chronic airway diseases.

机构信息

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Flinders University - College of Medicine and Public Health, Adelaide, South Australia, Australia.

出版信息

Expert Rev Respir Med. 2021 Sep;15(9):1229-1238. doi: 10.1080/17476348.2021.1928496. Epub 2021 Jul 2.

Abstract

: There is sparse literature evidence in the spirometric patterns of adult Indigenous Australians with and without chest computed tomography (CT)-proven chronic airway diseases (CADs).: Participants spirometry testing graded as acceptable for quality and had a chest CT scan showing radiographic evidence of CADs were included for analysis.: Of the 1350 spirometric tests performed between 2012 and 2020, a total of 212 patients with a mean age of 53 years and 54% females were eligible to be included. One-third (30%) had normal chest CT (without CADs), 35% had predominant COPD, 19% bronchiectasis and 16% combined COPD and bronchiectasis. Percentage predicted values for forced vital capacity (FVC) and forced expiratory volume in one second (FEV) both pre- and post- bronchodilator were significantly reduced for all participants - FVC: CT-normal 64%, 65%; COPD 58%, 62%; bronchiectasis 54%, 54%; combined COPD and bronchiectasis 50%, 53%. FEV: CT-normal 62%, 65%; COPD 46%, 49%; bronchiectasis 48%,51%; combined COPD and bronchiectasis 36%,40%. FEV/FVC was only reduced for CT abnormality patients - CT-normal 96%,98%; COPD 77%,77%; bronchiectasis 87%,89%; combined COPD and bronchiectasis 71%,72%.: Restrictive spirometric pattern is common and an obstructive pattern with COPD, in isolation or when COPD coexists with bronchiectasis.

摘要

成人澳大利亚原住民的肺功能模式,无论是否存在胸部计算机断层扫描 (CT) 证实的慢性气道疾病 (CAD),相关文献证据都很少。

参与者的肺功能测试质量分级为可接受,并进行了胸部 CT 扫描,显示 CAD 的放射影像学证据,被纳入分析。

在 2012 年至 2020 年间进行的 1350 次肺功能测试中,共有 212 名平均年龄为 53 岁、女性占 54%的患者符合入选条件。三分之一(30%)的患者胸部 CT 正常(无 CAD),35%的患者主要患有 COPD,19%的患者患有支气管扩张症,16%的患者同时患有 COPD 和支气管扩张症。所有参与者的用力肺活量 (FVC) 和一秒用力呼气量 (FEV) 的预计百分比值均显著降低,无论是否使用支气管扩张剂——FVC:CT 正常 64%,65%;COPD 58%,62%;支气管扩张症 54%,54%;COPD 和支气管扩张症合并症 50%,53%。FEV:CT 正常 62%,65%;COPD 46%,49%;支气管扩张症 48%,51%;COPD 和支气管扩张症合并症 36%,40%。仅 CT 异常患者的 FEV/FVC 降低——CT 正常 96%,98%;COPD 77%,77%;支气管扩张症 87%,89%;COPD 和支气管扩张症合并症 71%,72%。

限制性肺功能模式很常见,阻塞性模式以 COPD 为主,也可能单独存在,或与支气管扩张症同时存在。

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