Hawassa University College of Medicine and Health Science, Hawassa, Ethiopia.
BMC Infect Dis. 2021 May 13;21(1):440. doi: 10.1186/s12879-021-06151-2.
Lower respiratory tract infection is a global problem accounting over 50 million deaths annually. Here, we determined the bacterial profile and antimicrobial susceptibility pattern of lower respiratory tract infections among adult patients attending at Tertiary Hospital, Southern Ethiopia.
A cross sectional study was conducted among adult patients with lower respiratory infection at the medical outpatient department of the Hospital. A sputum sample was collected and processed for bacterial culture and antimicrobial susceptibility test. Semi structured questionnaires were used to collect data. SPSS version 22 software was used for statistical analysis and a p value of < 0.05 was considered as statistically significant.
Out of 406 sputum samples of participants 136(33.5%) were culture positive for 142 bacterial isolates. Klebsiella pneumoniae 36(25.4%) was the predominant isolate followed by Pseudomonas species 25(17.6%). Gram-negative bacteria were sensitive to cefepime (86.0%) and ciprofloxacin (77.8%) antibiotics while gram-positive (76.5%) to clindamycin.
Community acquired lower respiratory tract Infection was highly prevalent in the study area and the isolates showed resistant to common antibiotics such as ampicillin, augmentin, ceftazidime and tetracycline. Therefore, culture and susceptibility test is vital for appropriate management of lower respiratory tract infection in the study area.
下呼吸道感染是一个全球性问题，每年导致超过 5000 万人死亡。在这里，我们确定了在埃塞俄比亚南部一家三级医院就诊的成年患者下呼吸道感染的细菌谱和抗菌药物敏感性模式。
在医院的门诊部对患有下呼吸道感染的成年患者进行了一项横断面研究。采集痰标本进行细菌培养和抗菌药物敏感性试验。使用半结构化问卷收集数据。使用 SPSS 版本 22 软件进行统计分析，p 值<0.05 被认为具有统计学意义。
在 406 份参与者的痰样本中，有 136 份（33.5%）培养出 142 株细菌分离株。肺炎克雷伯菌 36 株（25.4%）是主要分离株，其次是假单胞菌 25 株（17.6%）。革兰氏阴性菌对头孢吡肟（86.0%）和环丙沙星（77.8%）抗生素敏感，而革兰氏阳性菌（76.5%）对克林霉素敏感。
在研究区域，社区获得性下呼吸道感染非常普遍，且分离株对氨苄西林、阿莫西林克拉维酸、头孢他啶和四环素等常用抗生素表现出耐药性。因此，在研究区域，培养和药敏试验对于下呼吸道感染的适当治疗至关重要。
