评价极低出生体重儿生后第 4 周代谢性骨病的放射学证据。
Evaluation of radiologic evidence of metabolic bone disease in very low birth weight infants at fourth week of life.
机构信息
Department of Neonatology, Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Department of Neonatology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
出版信息
J Perinatol. 2021 Nov;41(11):2668-2673. doi: 10.1038/s41372-021-01065-y. Epub 2021 May 13.
AIM
The aim of this study is to determine the incidence of metabolic bone disease (MBD) and assess the risk factors for development radiologic evidence of MBD.
METHODS
Preterm infants with gestational age ≤32 weeks and birth weight ≤1500 g were included in this prospective study. Metabolic bone disease was defined as hypophosphatemia (phosphorus levels <4 mg/dl), ALP levels >450 U/L, or radiologic findings of MBD at four weeks of age.
RESULTS
The study included 254 infants (gestational age: 29 (27-30) weeks, birth weight: 1130 g (960-1300)). Metabolic bone disease was diagnosed in 96 patients (37%); 48 infants had only radiologic evidence of MBD, 24 infants had only biochemical diagnosis of MBD, and 24 infants had both radiologic evidence of MBD and biochemical diagnosis of MBD.
CONCLUSIONS
Our results showed that radiologic evidence of MBD existed in some infants with normal biochemical results. That finding may guide further development of screening programs for MBD.
目的
本研究旨在确定代谢性骨病（MBD）的发病率，并评估发生 MBD 放射学证据的危险因素。
方法
本前瞻性研究纳入了胎龄≤32 周且出生体重≤1500g 的早产儿。代谢性骨病定义为低磷血症（磷水平＜4mg/dl）、碱性磷酸酶（ALP）水平＞450U/L，或在 4 周龄时出现 MBD 的放射学表现。
结果
本研究纳入了 254 例婴儿（胎龄：29（27-30）周，出生体重：1130g（960-1300））。96 例（37%）婴儿诊断为代谢性骨病；48 例婴儿仅存在 MBD 的放射学证据，24 例婴儿仅存在 MBD 的生化诊断，24 例婴儿同时存在 MBD 的放射学证据和生化诊断。
结论
我们的结果表明，一些生化结果正常的婴儿存在 MBD 的放射学证据。这一发现可能指导进一步制定 MBD 的筛查计划。
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