Schwaab G, Micheau C, Le Guillou C, Pacheco L, Marandas P, Domenge C, Richard J M, Wibault P
Department of Otolaryngology, Head and Neck Surgery, Institut Gustave-Roussy, Villejuif, France.
Laryngoscope. 1988 Aug;98(8 Pt 1):872-6. doi: 10.1288/00005537-198808000-00016.
Olfactory esthesioneuroma is a rare malignant tumor arising in the olfactory epithelium. Forty cases observed at the Institut Gustave-Roussy from 1956 to 1987 are reported. This tumor usually grows slowly and is usually local, but it is important to be aware of the possibility of lymph node involvement (17%) and, particularly, of rapid development of distant metastases (25%), usually within 6 months. CT scan, and more recently, NMR have proved to be of value in choosing the surgical approach. In view of the usual point of departure, a combined neurosurgical and transfacial approach seems to be a satisfactory approach for obtaining oncological control of the lesion. The role of chemotherapy is discussed. The main prognostic factors seem to be the size of the lesion, the intracranial extension, and the lymph node involvement.
嗅神经母细胞瘤是一种起源于嗅上皮的罕见恶性肿瘤。本文报告了1956年至1987年在古斯塔夫 - 鲁西研究所观察到的40例病例。这种肿瘤通常生长缓慢，多为局部病变，但必须注意其有发生淋巴结转移的可能性（17%），特别是远处转移迅速发展的可能性（25%），通常在6个月内发生。CT扫描以及最近的核磁共振成像已被证明在选择手术入路方面具有价值。鉴于其通常的发病部位，神经外科和经面部联合入路似乎是对该病变进行肿瘤学控制的一种令人满意的方法。文中还讨论了化疗的作用。主要的预后因素似乎是病变大小、颅内扩展情况和淋巴结受累情况。
